ArticleBritish journal of pharmacology1994
Block of ATP-sensitive K+ channels in isolated mouse pancreatic beta-cells by 2,3-butanedione monoxime.
Article in British journal of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Analysis of KThe Malaysian journal of medical sciences : MJMS · 2021Article
- Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KEndocrinology, diabetes & metabolism · 2018Article
- Evaluation of e-liquid toxicity using an open-source high-throughput screening assay.PLoS biology · 2018Article
- Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.The Journal of general physiology · 2001Article
- Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells.The Journal of physiology · 2001Article
- Action of 2,3-butanedione monoxime on capacitance and electromotility of guinea-pig cochlear outer hair cells.The Journal of physiology · 2001Article
- G proteins modulate D2 receptor-coupled K(ATP) channels in rat dopaminergic terminals.Neurochemical research · 2000Article
- Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells.The Biochemical journal · 2000Article
- Ligand-insensitive state of cardiac ATP-sensitive K+ channels. Basis for channel opening.The Journal of general physiology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. The patch-clamp technique has been used to examine the action of the chemical phosphatase 2,3-butanedione monoxime (BDM) on ATP-sensitive K+ channels (KATP-channels) from mouse isolated pancreatic beta-cells in the absence of ATP and Mg2+. 2. BDM reversibly inhibited whole-cell KATP-currents with a concentration for half maximal inhibition (K(i)) of 15 +/- 1 mM and a Hill coefficient (n) of 2.5 +/- 0.2 (n = 4). 3. In outside-out patches, external BDM reversibly reduced the activity of single KATP-channels with an affinity similar to that observed in whole-cell recordings (K(i) = 11 +/- 3 mM, n = 2.0 +/- 0.3, n = 7). In inside-out patches, internally applied BDM also reversibly blocked the activity of KATP-channels (K(i) = 31 +/- 2 mM, n = 2.2 +/- 0.4, n = 8). In both excised patch configurations, BDM decreased the mean open life-time and the burst duration, thereby producing a decrease in the channel open probability. The drug had no effect on the short intraburst closed times. 4. BDM had no effect on the single-channel current amplitude. 5. The results suggest that BDM blocks the KATP-channel directly, by mechanisms independent of channel dephosphorylation.
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