ArticleThe American journal of pathology1994
Oncostatin-M is an autocrine growth factor in Kaposi's sarcoma.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- The clinical relevance of OSM in inflammatory diseases: a comprehensive review.Frontiers in immunology · 2023Review
- HIV-Associated Cancer Biomarkers: A Requirement for Early Diagnosis.International journal of molecular sciences · 2021Review
- Role of Pattern Recognition Receptors in KSHV Infection.Cancers · 2018Review
- Biomarkers of HIV-associated Cancer.Biomarkers in cancer · 2014Review
- Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.Cell host & microbe · 2013Article
- Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- KSHV-induced notch components render endothelial and mural cell characteristics and cell survival.Blood · 2010Article
- Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.Journal of virology · 2007Article
- Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis.Microbiology and molecular biology reviews : MMBR · 2003Review
- Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells.The Biochemical journal · 2001Article
- Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells.The American journal of pathology · 2000Article
- Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression.Journal of virology · 1999Article
- Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.Journal of virology · 1998Article
- Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.The American journal of pathology · 1998Article
- Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules.The Journal of clinical investigation · 1997Article
- Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells.The Journal of clinical investigation · 1997Article
- Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- IL-4R expression in AIDS-KS cells and response to rhIL-4 and IL-4 toxin (DAB389-IL-4).Investigational new drugs · 1997Article
- Human herpesvirus 8 encodes a homolog of interleukin-6.Journal of virology · 1997Article
- Expression and cytokine regulation of glucocorticoid receptors in Kaposi's sarcoma.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Oncostatin-M is a cytokine produced by macrophages and activated T lymphocytes that has recently been shown to be a mitogen for AIDS-related Kaposi's sarcoma (KS)-derived spindle cells. The significance of oncostatin-M production in AIDS-related KS in vivo, however, remains unknown. In this study we wanted to determine whether oncostatin-M is expressed in vivo in patients with HIV-I-related KS, define the cell types that express this cytokine, and compared with the control tissues from HIV-I-negative individuals. A second objective of our study was to define the expression of oncostatin-M in AIDS-KS-derived spindle cell isolates cultured in vitro and to determine whether oncostatin-M is an autocrine growth factor for these KS cells. We have determined that oncostatin-M is not expressed in any of the several organs examined in control cases, whereas the tumor tissue obtained from the skin biopsies of HIV-I-infected cases with KS displayed oncostatin-M expression in the spindle cell components of the tumor, as well as the cells lining the vascular structures, smooth muscle cells lining the eccrine sweat glands, and the epidermal layers of the skin. Furthermore, uninvolved skin of patients with HIV-related KS express oncostatin-M in the cells lining normal vessels. The mRNA polymerase chain reaction analysis confirmed findings in the primary tissues and showed expression in all of the AIDS-KS-derived spindle cell isolates examined. We have also shown with the use of oncostatin-M-specific antisense oligodeoxynucleotides that KS cell proliferation is inhibited, which correlated with a more precipitous decline in the production of interleukin-6 by these cells. We conclude that oncostatin-M is only expressed in the skin and KS tumor of HIV-I-infected individuals. Furthermore, we provide evidence that oncostatin-M is an autocrine growth factor for KS.
Indexed as
Identifiers
8030759PMC1887313W2344243920What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.