ArticleThe American journal of pathology1994
NM23 protein in neoplastic and nonneoplastic thyroid tissues.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy.Molecular cancer · 2025Review
- Article
- Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis.Cancer letters · 2010Review
- Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase.British journal of cancer · 2007Article
- Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior.Virchows Archiv : an international journal of pathology · 2006Article
- Expression of NM23 in human melanoma progression and metastasis.British journal of cancer · 1996Article
- Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.Virchows Archiv : an international journal of pathology · 1996Article
- Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.Virchows Archiv : an international journal of pathology · 1995Article
- Immunohistochemical analysis of nm23 protein expression in malignant bone tumors.Journal of cancer research and clinical oncology · 1995Article
- nm23 protein expression in metastatic and non-metastatic tongue squamous cell carcinoma.Brazilian journal of otorhinolaryngologyArticle
- Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.Integrative cancer science and therapeuticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of nm23 gene products has been associated with a lower metastatic potential and better outcome in malignant tumors. We have used immunohistochemistry to study the expression of nm23 protein in thyroid tissues from 101 patients consisting of 78 malignant neoplasms, 13 adenomas, and 10 other benign conditions. Cytoplasmic staining for nm23 protein was identified in normal tissues and in most benign and malignant lesions and did not correlate with either histological type of clinical outcome. Nuclear staining was seen in 93% of normal tissues and in 29% of primary carcinomas of the thyroid and was associated with a longer disease-free survival (P = 0.03). Membranous staining was present in some tumors but absent in normal thyroid. In conclusion, nm23 protein has a combined pattern of distribution among subcellular compartments in thyroid tissues. Although there was no significant association between cytoplasmic or membranous expression and histological type of tumor or survival nm23 nuclear expression may be a useful marker in assessing the evolution of thyroid tumors.
Indexed as
Identifiers
8030752PMC1887288W102369865What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.