ArticleNucleic acids research1994
Retinoic acid-mediated activation of HNF-3 alpha during EC stem cell differentiation.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.Development (Cambridge, England) · 2017Article
- RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms.Science signaling · 2016Article
- Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk.Molecular and cellular endocrinology · 2012Review
- FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo.Molecular and cellular biology · 2004Article
- Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.The American journal of pathology · 2004Article
- Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.Molecular and cellular biology · 2003Article
- Adenovirus-mediated increase of HNF-3 levels stimulates expression of transthyretin and sonic hedgehog, which is associated with F9 cell differentiation toward the visceral endoderm lineage.Gene expression · 2001Article
- Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta.Gene expression · 2001Article
- E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway.Nucleic acids research · 1998Article
- The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.Molecular and cellular biology · 1997Article
- The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression.Molecular and cellular biology · 1996Article
- Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells.Molecular and cellular biology · 1996Article
- Identification of a transthyretin enhancer site that selectively binds the hepatocyte nuclear factor-3 beta isoform.Gene expression · 1996Article
- Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting.Nucleic acids research · 1995Article
- Decreased expression of hepatocyte nuclear factor 3 alpha during the acute-phase response influences transthyretin gene transcription.Molecular and cellular biology · 1995Article
- Overexpression of the E2F-1 transcription factor gene mediates cell transformation.Gene expression · 1995Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present evidence demonstrating that the liver-enriched transcription factor HNF-3 alpha is activated upon retinoic acid-induced differentiation of mouse F9 embryonal carcinoma cells. We have detected increases in the DNA binding activity and mRNA level of HNF-3 alpha. Both are reflections of the actual activation mechanism at the level of transcriptional initiation, which we showed with the help of HNF-3 alpha promoter constructs. Time course studies clearly show that HNF-3 alpha activation is a transient event. Employing Northern blots, HNF-3 alpha mRNA can be detected between 16 and 24 hours post-differentiation, reaches its zenith at approximately 1 day, and then declines to virtually undetectable levels. F9 cells can give rise to three distinct differentiated cell types; visceral endoderm, parietal endoderm, and primitive endoderm. We have clearly shown that HNF-3 alpha stimulation occurs upon primitive endoderm formation. In addition, the transcription factor is also activated during the induction of cell lineages that give rise to parietal and visceral endoderm. HNF-3 alpha stimulation upon visceral endoderm differentiation is accompanied by the activation of HNF-3 target genes such as transthyretin, suggesting that HNF-3 alpha is involved in the developmental activation of this gene. In contrast, HNF-3 alpha target genes in parietal and primitive endoderm have yet to be identified. However, the stimulation of HNF-3 alpha during primitive endoderm formation, which is an extremely early event during murine embryogenesis, points towards a role for the factor in crucial determination processes that occur early during development.
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