ArticleNucleic acids research1994
Allele-specific expression of a variant-specific surface protein (VSP) of Giardia lamblia.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Sirtuins of parasitic protozoa: in search of function(s).Molecular and biochemical parasitology · 2012Review
- The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution.BMC genomics · 2010Article
- Unusually low levels of genetic variation among Giardia lamblia isolates.Eukaryotic cell · 2007Article
- Cytogenetic evidence for diversity of two nuclei within a single diplomonad cell of Giardia.Chromosoma · 2007Article
- The two nuclei of Giardia each have complete copies of the genome and are partitioned equationally at cytokinesis.Eukaryotic cell · 2002Article
- The abundance of sterile transcripts in Giardia lamblia.Nucleic acids research · 2001Article
- Biology of Giardia lamblia.Clinical microbiology reviews · 2001Review
- Structure of a frequently rearranged rRNA-encoding chromosome in Giardia lamblia.Nucleic acids research · 1995Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The surfaces of Giardia lamblia trophozoites demonstrate variable expression of a set of cysteine-rich surface proteins, called variant-specific surface proteins (VSP). The cloned Giardia line, WBA6, expresses a 170 kD VSP (VSPA6 or CRP170) which contains approximately 18 to 23 copies of a 65 amino acid repeat. We have cloned the expressed vspA6 gene containing 23 repeats from a genomic library as well as copies of the vspA6 gene with only 8 or 9 repeats from both WBA6 and from WB1269, a cloned line derived from WBA6 which has lost the expressed copy of the gene. The recombinant clones containing the genes with only 8 or 9 repeats have 8 nucleotide substitutions in the coding region. All the recombinant clones map to the same chromosomal location, yet RNA sequencing and comparison with the transcript size indicate that only the clone with 23 repeats contains a gene producing a stable transcript. The most likely interpretation of these data is that G.lamblia trophozoites contain multiple alleles of the vspA6 gene of which only one is expressed.
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