ArticleNucleic acids research1994
Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Cysteine Mutagenesis of a Group II Intron-Encoded Protein Supports Splicing, Mobility, and Site-Specific Labeling.Biochemistry · 2025Article
- Comparative chloroplast genome analyses ofFrontiers in plant science · 2022Article
- An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts.RNA biology · 2022Article
- Organellar Introns in Fungi, Algae, and Plants.Cells · 2021Review
- Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast.Cellular and molecular life sciences : CMLS · 2020Article
- Unraveling the role of the enigmatic MatK maturase in chloroplast group IIA intron excision.Plant direct · 2020Article
- An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron.RNA (New York, N.Y.) · 2018Article
- Functionality ofFrontiers in molecular biosciences · 2016Article
- Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution.Microbiology spectrum · 2015Review
- Evolution of group II introns.Mobile DNA · 2015Article
- Group II introns: mobile ribozymes that invade DNA.Cold Spring Harbor perspectives in biology · 2011Review
- Learning to live together: mutualism between self-splicing introns and their hosts.BMC biology · 2011Review
- Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase.RNA (New York, N.Y.) · 2010Article
- Lateral transfer of introns in the cryptophyte plastid genome.Nucleic acids research · 2008Article
- Evaluating evolutionary constraint on the rapidly evolving gene matK using protein composition.Journal of molecular evolution · 2008Article
- Dispersion of the RmInt1 group II intron in the Sinorhizobium meliloti genome upon acquisition by conjugative transfer.Nucleic acids research · 2007Article
- A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Domain structure and three-dimensional model of a group II intron-encoded reverse transcriptase.RNA (New York, N.Y.) · 2005Article
- The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing.Molecular and cellular biology · 2003Article
- Putative proteins related to group II intron reverse transcriptase/maturases are encoded by nuclear genes in higher plants.Nucleic acids research · 2003Article
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7 authors.
Funding
Abstract
Six mutations blocking the function of a seven intron form of the mitochondrial gene encoding subunit I of cytochrome c oxidase (COXI) and mapping upstream of exon 3 were isolated and characterized. A cis-dominant mutant of the group IIA intron 1 defines a helical portion of the C1 substructure of domain 1 as essential for splicing. A trans-recessive mutant confirms that the intron 1 reading frame encodes a maturase function. A cis-dominant mutant in exon 2 was found to have no effect on the splicing of intron 1 or 2. A trans-recessive mutant, located in the group IIA intron 2, demonstrates for the first time that intron 2 encodes a maturase. A genetic dissection of the five missense mutations present in the intron 2 reading frame of that strain demonstrates that the maturase defect results from one or both of the missense mutations in a newly-recognized conserved sequence called domain X.
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