Evidence map›Paper›PMID 8029009›Full record

ArticleNucleic acids research1994

A novel growth-inducible gene that encodes a protein with a conserved cold-shock domain.

K Ito, K Tsutsumi, T Kuzumaki, P F Gomez, K Otsu, K Ishikawa

Abstract read
In one paragraph

Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
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  6. Article
  7. Review
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  14. Article
  15. Hereditary fructose intolerance.Journal of medical genetics · 1998
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

K ItoDepartment of Biochemistry, Yamagata University School of Medicine, Japan.
K Tsutsumi
T Kuzumaki
P F Gomez
K Otsu
K Ishikawa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have isolated a cDNA that encodes a novel member of the Y-box binding protein family, termed as RYB-a (Rat Y-box Binding protein-a). RYB-a is a 31 kDa protein that contains a conserved cold-shock domain and an amino acid alignment similar to those of charge zipper proteins. Expression of RYB-a mRNA was highly abundant in the skeletal muscle, spleen, and fetal liver. The expression is very low in new-born and adult livers, suggesting its expression is under developmental regulation. In addition, the expression of RYB-a mRNA was induced in the liver during regeneration and by stimulation of quiescent fibroblast cells with serum. Induction in the fibroblasts was inhibited by treating the cell with a specific tyrosine kinase inhibitor, genistein or by detachment of cell-adhesion. Since both treatments are known to inhibit G1 cells to enter S phase, RYB-a gene is thought to be a member of growth-inducible genes.

Indexed as

Gene Expression Regulation3T3 CellsAmino Acid SequenceAnimalsBase SequenceCell DivisionCells, CulturedCold TemperatureConserved SequenceDNADNA-Binding ProteinsHumansMiceMolecular Sequence DataOrgan SpecificityRatsDNADNA-Binding ProteinsRNA, MessengerYbx3 protein, rat

Identifiers

PMID8029009
PMCPMC308118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.