ArticleNucleic acids research1994
Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- hnRNPs: roles in neurodevelopment and implication for brain disorders.Frontiers in molecular neuroscience · 2024Review
- Research Progress on the Structural and Functional Roles of hnRNPs in Muscle Development.Biomolecules · 2023Review
- miRNA-Based Regulation of Alternative RNA Splicing in Metazoans.International journal of molecular sciences · 2021Review
- hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.Biology · 2021Review
- Identification of Rare Copy Number Variants Associated With Pulmonary Atresia With Ventricular Septal Defect.Frontiers in genetics · 2019Article
- Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.Open biology · 2017Article
- Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival.Molecular neurobiology · 2016Article
- Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors.PloS one · 2014Article
- Systematic discovery of structural elements governing stability of mammalian messenger RNAs.Nature · 2012Article
- Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.Human molecular genetics · 2009Review
- The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation.The Journal of cell biology · 2000Article
- A novel family of plant splicing factors with a Zn knuckle motif: examination of RNA binding and splicing activities.Plant molecular biology · 1999Article
- Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.RNA (New York, N.Y.) · 1998Article
- Growth-dependent and growth-independent translation of messengers for heterogeneous nuclear ribonucleoproteins.Nucleic acids research · 1997Article
- Clinical and immunological aspects of autoantibodies to RA33/hnRNP-A/B proteins--a link between RA, SLE and MCTD.Molecular biology reports · 1996Review
- Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.The EMBO journal · 1994Article
- Recurrent 8q11-13 Aberrations Leading toCancer genomics & proteomicsArticle
- Evolution of SR protein and hnRNP splicing regulatory factors.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneous nuclear ribonucleoprotein (hnRNP) A2 belongs, with A1, B1 and B2, to the basic protein subset of the hnRNP complex in mammalian cells. All these proteins share a modular structure consisting of two conserved RNA binding domains linked to less conserved Gly-rich domains (2xRBD-Gly). In the framework of our studies on the genetic basis of hnRNP proteins structure and diversity we have isolated and sequenced the A2 gene and compared it to the previously described A1 gene. The A2 gene, which exists in a single copy on Ch. 7 band p15, is split in 12 exons including an alternatively spliced 36 nt mini exon specific for the human hnRNP protein B1. In this work we show that the intron/exon organisation of the A2 gene is identical to that of the A1 gene over the entire length, indicating a common origin by gene duplication. Moreover the comparison of corresponding exons evidences significant conservation also in the apparently divergent Gly-rich domains that could define previously unenvisaged structural and/or functional motifs. The A2 gene promoter is also analysed in comparison to that of the A1 gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.