ArticleMolecular & general genetics : MGG1994
Shared control of maltose induction and catabolite repression of the MAL structural genes in Saccharomyces.
Article in Molecular & general genetics : MGG, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Maltose accumulation-induced cell death in Saccharomyces cerevisiae.FEMS yeast research · 2024Article
- Gly-46 and His-50 of yeast maltose transporter Mal21p are essential for its resistance against glucose-induced degradation.The Journal of biological chemistry · 2009Article
- Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity.Applied and environmental microbiology · 2004Article
- Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltose.Applied and environmental microbiology · 2002Article
- Improved properties of baker's yeast mutants resistant to 2-deoxy-D-glucose.Applied and environmental microbiology · 2001Article
- Alleviation of glucose repression of maltose metabolism by MIG1 disruption in Saccharomyces cerevisiae.Applied and environmental microbiology · 1996Article
- A two-reporter gene system for the analysis of bi-directional transcription from the divergent MAL6T-MAL6S promoter in Saccharomyces cerevisiae.Current genetics · 1995Article
- MIG1-dependent and MIG1-independent glucose regulation of MAL gene expression in Saccharomyces cerevisiae.Current genetics · 1995Article
- Purification and binding properties of the Mal63p activator of Saccharomyces cerevisiae.Current genetics · 1995Article
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4 authors at 1 institution in 1 country.
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Abstract
Maltose utilization in yeast requires the presence of any one of the five unlinked, homologous MAL loci. Transcription of the two structural genes MALT (permease) and MALS (maltase) is induced by maltose and catabolite-repressed by glucose. MAL6T and MAL6S share a common 5' intergenic sequence; deletion studies within this sequence revealed a bi-directionally functioning upstream activation sequence (UASM) consisting of four 11 bp homologous sites. Activation of these sites by the MALR protein results in the coordinate expression of MAL6T and MAL6S. The basal promoter activates MALS expression to a greater extent than MALT and is located in a region that overlaps UASM. Deletion of several subsites within the UASM has an asymmetric effect on MAL gene expression, having a greater affect on MALT than on MALS. Catabolite repression of MAL6T and MAL6S by glucose is controlled at several levels. Using disruption mutants, the positively acting MAL1R protein was also found to play a role in catabolite repression of MAL6T and MAL6S.
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