ArticleJournal of clinical microbiology1994
Investigation of the sequence of colonization and candidemia in nonneutropenic patients.
Article in Journal of clinical microbiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients: a systematic review.Critical care (London, England) · 2007Pooled it
- Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial.Critical care (London, England) · 2012Trial
- Oral nystatin prophylaxis of Candida spp. colonization in ventilated critically ill patients.Intensive care medicine · 2005Trial
- Long COVID and gut candidiasis: What is the existing relationship?World journal of gastroenterology · 2024Review
- Cinnamaldehyde Loaded Poly(lactide-co-glycolide) (PLGA) Microparticles for Antifungal Delivery Application against ResistantPlants (Basel, Switzerland) · 2023Article
- Microbiota signatures associated with invasiveFrontiers in cellular and infection microbiology · 2023Article
- Distribution of Yeast Species and Risk Factors of Oral Colonization after Oral-Care Education among the Residents of Nursing Homes.Journal of fungi (Basel, Switzerland) · 2022Article
- The Glyoxylate Cycle Is Involved in White-Opaque Switching inJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses.Cell host & microbe · 2019Article
- Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.mBio · 2018Article
- The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.Antimicrobial agents and chemotherapy · 2017Article
- Article
- Echinocandin Resistance in Candida.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Outcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization.Intensive care medicine · 2015Observational
- Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient management.Drugs · 2014Review
- Yeast oropharyngeal colonization in human immunodeficiency virus-infected patients in central taiwan.Mycopathologia · 2014Article
- Extracellular enolase of Candida albicans is involved in colonization of mammalian intestinal epithelium.Frontiers in cellular and infection microbiology · 2014Article
- Microsatellite genotyping clarified conspicuous accumulation of Candida parapsilosis at a cardiothoracic surgery intensive care unit.Journal of clinical microbiology · 2012Article
- Investigation of a cluster of Candida albicans invasive Candidiasis in a neonatal intensive care unit by pulsed-field gel electrophoresis.TheScientificWorldJournal · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among neutropenic patients with hematologic malignancies, candidemia has been shown to arise typically from autoinfection after colonization. In patients without neutropenia, we examined the similarities of strains colonizing or infecting various body sites and those subsequently causing Candida bloodstream infections. Strain similarity was examined by karyotyping and restriction endonuclease analysis of genomic DNA (REAG) by using two restriction enzymes (SfiI and BssHII). The banding patterns of 42 isolates from 19 patients were independently evaluated in a blinded fashion by three observers. The interobserver reliability measured with a generalized kappa statistic was 0.59 for karyotyping, 0.84 for REAG with SfiI, and 0.88 for REAG with BssHII (P < 0.001 for each). REAG classified the initial colonizing or infecting isolate and subsequent blood isolates as identical in 16 patients (84%). The mean duration of colonization or infection prior to a positive blood culture was 5 and 23 days in patients infected with related and unrelated isolates, respectively (P = 0.14; 95% confidence interval = -14.5 to 50.5). Karyotyping results matched the REAG results for isolates from 14 of the 19 patients (74%). In patients infected with identical isolates, the initial isolate was most frequently recovered from the urine (n = 5) or vascular catheter tips (n = 4). In the five subjects with organisms showing disparate results between the methods, karyotyping revealed different banding patterns, whereas REAG suggested that the isolates were identical. Candida colonization or infection with an identical strain frequently precedes bloodstream infection in nonneutropenic patients. Future studies should evaluate whether patients at high risk for candidemia and who have vascular catheter or urine samples that are positive for a Candida on culture should be treated empirically.
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