ArticleHistochemistry1994
Alpha 6 integrin distribution in human embryonic and adult tissues.
Article in Histochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Cell Adhesion Molecules in Fibrotic Diseases.Biomedicines · 2023Review
- Article
- Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis.Nature communications · 2016Article
- Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1.Burns & trauma · 2016Article
- NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.PLoS biology · 2012Article
- The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion.Journal of cellular physiology · 2010Review
- Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition.Reproduction (Cambridge, England) · 2007Article
- PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane.The Journal of experimental medicine · 2002Article
- Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the alpha6beta1 integrin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Identification of a novel structural variant of the alpha 6 integrin.The Journal of biological chemistry · 2001Article
- Integrin alpha 6 expression in human prostate carcinoma cells is associated with a migratory and invasive phenotype in vitro and in vivo.Clinical & experimental metastasis · 1995Article
- Integrins and extracellular matrix-proteins in the different components of the Wilms' tumour.Virchows Archiv : an international journal of pathology · 1994Article
- Laminin isoforms in endothelial and perivascular basement membranes.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha 6 integrin is an adhesion molecule that connects cells with extracellular matrix molecules of the laminin family. The laminin interaction seems to be essential for cell differentiation during embryogenesis and for the subsequent maintenance of tissue integrity in the adult. Alpha 6 integrin can also interact with laminin-independent cellular ligands and in this way plays a role in homing of leucocytes. Furthermore, in cancer biology alpha 6 integrin has an important role in metastasis and as a possible new prognostic factor; exact knowledge of alpha 6 integrin distribution in normal human tissues is therefore a crucial element. By immuno-histochemical methods we have screened alpha 6 integrin expression of representative human tissues from the adult and the embryonic organism. All tested epithelia were alpha 6 integrin positive, except for the endocrine cells of the pancreas and the adrenal glands. Heterogeneous staining was found on non-epithelial tissues. Strong staining was evident in peripheral nerves (Schwann cells), germ and Sertoli cells, endothelia, and smooth muscle cells of the myometrium. Weak staining was found in nerve cells of the stratum granulosum, the microglia, Kupffer's cells and stromal cells of the ovary. All fibroblasts, striated muscle cells and astrocytes were negative. The tissue distribution of alpha 6 integrin and the semi-quantitative estimation of their expression level should provide a better understanding of alpha 6 integrin function under normal and pathological conditions, in particular in tumour progression.
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