ReviewTransgenic research1994
Reporter genes in transgenic mice.
Review in Transgenic research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 83 citations in OpenAlex.
- Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mapping.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Article
- Analysis of Gene Expression Using lacZ Reporter Mouse Lines.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Tracing Gene Expression Through Detection of β-galactosidase Activity in Whole Mouse Embryos.Journal of visualized experiments : JoVE · 2018Article
- Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research.Investigative ophthalmology & visual science · 2017Article
- Overview and assessment of the histochemical methods and reagents for the detection of β-galactosidase activity in transgenic animals.Anatomical science international · 2016Review
- A reporter mouse line with doxycyclin-inducible expression of β-glucosidase.Histochemistry and cell biology · 2014Article
- Rapid identification of targeted transgene integrations in ES cells by fluorescence detection.Transgenic research · 2014Article
- GFAP expression as an indicator of disease severity in mouse models of Alexander disease.ASN neuro · 2013Article
- Improved methods for detection of β-galactosidase (lacZ) activity in hard tissue.Histochemistry and cell biology · 2012Article
- Conditional bicistronic Cre reporter line expressing both firefly luciferase and β-galactosidase.Molecular imaging and biology · 2011Article
- Characterization of a heat resistant beta-glucosidase as a new reporter in cells and mice.BMC biology · 2010Article
- Dual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein.Journal of neurochemistry · 2009Article
- The genetics of regulatory variation in the human genome.Human genomics · 2005Review
- Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.Molecular and cellular biology · 2004Article
- Article
- A family of at least seven beta-galactosidase genes is expressed during tomato fruit development.Plant physiology · 2000Article
- Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector.Oncogene · 1999Review
- Human placental alkaline phosphatase as a histochemical marker of gene expression in transgenic mice.Transgenic research · 1996Article
- FLP-mediated site-specific recombination in microinjected murine zygotes.Transgenic research · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although in vivo models utilizing endogenous reporter genes have been exploited for many years, the use of reporter transgenes to dissect biological issues in transgenic animals has been a relatively recent development. These transgenes are often, but not always, of prokaryotic origin and encode products not normally associated with eukaryotic cells and tissues. Some encode enzymes whose activities are detected in cell and tissue homogenates, whereas others encode products that can be detected in situ at the single cell level. Reporter genes have been used to identify regulatory elements that are important for tissue-specific gene expression or for development; they have been used to produce in vivo models of cancer; they have been employed for the study of in vivo mutagenesis; and they have been used as a tool in lineage analysis and for marking cells in transplantation experiments. The most commonly used in situ reporter gene is lacZ, which encodes a bacterial beta-galactosidase, a sensitive histochemical marker. Although it has been used with striking success in cultured cells and in transgenic mouse embryos, its postnatal in vivo expression has been unreliable and disappointing. Nevertheless, the ability to express reporter genes in transgenic mice has been an invaluable resource, providing insights into in vivo biological mechanisms. The development of new in vivo models, such as those in which expression of transgenes can be activated or repressed, should produce transgenic animal systems that extend our capacity to address heretofore unresolved biological questions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.