Trial reportArchives of disease in childhood1993
Increased airway responsiveness in children of low birth weight at school age: effect of topical corticosteroids.
Trial report in Archives of disease in childhood, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2021Guideline
- Inhaled beclomethasone versus placebo for chronic asthma.The Cochrane database of systematic reviews · 2005Pooled it
- Inhaled steroids for episodic viral wheeze of childhood.The Cochrane database of systematic reviews · 2000Pooled it
- Chronic respiratory morbidity and wheeze after preterm birth: a narrative review.Frontiers in pediatrics · 2026Review
- Evolving treatment for prematurity-associated lung disease.Translational pediatrics · 2024Article
- Summary for Clinicians: Clinical Practice Guidelines for Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease.Annals of the American Thoracic Society · 2022Article
- Addressing the risk domain in the long-term management of pediatric asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Review
- Predicting Lung Health Trajectories for Survivors of Preterm Birth.Frontiers in pediatrics · 2020Review
- Article
- A 24-year-old woman with episodes of shortness of breath, cough and wheezing.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Article
- Peripheral blood lymphocyte subpopulations in schoolchildren born very preterm.Archives of disease in childhood. Fetal and neonatal edition · 1999Article
- Chronic lung disease of prematurity: are we too cautious with steroids?European journal of pediatrics · 1994Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of treatment with topical inhaled corticosteroids was assessed in 15 children of low birth weight (mean (SD) birth weight 1435 (268) g, gestational age 30.5 (2.9) weeks, age at study 8.2 (0.4) years) who were symptomatic and showed a positive airway response to histamine aerosol. The study was of a double blind, placebo controlled, crossover design with four week long treatment periods with inhaled beclomethasone dipropionate (400 micrograms daily) or placebo. Daily symptom scores were recorded and physiological measurements were performed at the beginning and end of each treatment period. There was no significant difference in respiratory symptom score, baseline airway function, or the airway response to histamine between treatment periods. The findings argue against an inflammatory basis for airway hyper-responsiveness in these children and raise questions as to its pathophysiological basis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.