ArticleProceedings of the National Academy of Sciences of the United States of America1994
Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 140 citations in OpenAlex.
- Gap junction protein beta 5 interacts with Gαi3 to promote Akt activation and cervical cancer cell growth.Cell death & disease · 2025Article
- Regulation of the gap junction interplay during postnatal development in the rat epididymis.Cell and tissue research · 2024Article
- Contribution of Keratinocytes in Skin Cancer Initiation and Progression.International journal of molecular sciences · 2024Review
- Identification and validation of a gap junction protein related signature for predicting the prognosis of renal clear cell carcinoma.Frontiers in oncology · 2024Article
- Article
- The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes.International journal of molecular sciences · 2022Review
- The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022Review
- Animal models for studying tumor microenvironment (TME) and resistance to lymphocytic infiltration.Cancer biology & therapy · 2018Review
- Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat.Biology of reproduction · 2016Article
- The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches.Frontiers in physiology · 2016Review
- Connexin26 Mutations Causing Palmoplantar Keratoderma and Deafness Interact with Connexin43, Modifying Gap Junction and Hemichannel Properties.The Journal of investigative dermatology · 2016Article
- Connexin hemichannels influence genetically determined inflammatory and hyperproliferative skin diseases.Pharmacological research · 2015Article
- Connexins and pannexins in the integumentary system: the skin and appendages.Cellular and molecular life sciences : CMLS · 2015Review
- Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.PLoS computational biology · 2015Article
- Article
- Connexins and pannexins: Coordinating cellular communication in the testis and epididymis.Spermatogenesis · 2011Article
- Gap junctions in inherited human disease.Pflugers Archiv : European journal of physiology · 2010Review
- Gap-junction channels dysfunction in deafness and hearing loss.Antioxidants & redox signaling · 2009Review
- Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system.The Journal of membrane biology · 2007Article
- Temporal regulation of connexin phosphorylation in embryonic and adult tissues.Biochimica et biophysica acta · 2005Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Gap junctional communication provides a mechanism for regulating multicellular activities by allowing the exchange of small diffusible molecules between neighboring cells. The diversity of gap junction proteins may exist to form channels that have different permeability properties. We report here that induction of terminal differentiation in mouse primary keratinocytes by calcium results in a specific switch in gap junction protein expression. Expression of alpha 1 (connexin 43) and beta 2 (connexin 26) gap junction proteins is down-modulated, whereas that of beta 3 (connexin 31) and beta 4 (connexin 31.1) proteins is induced. Although both proliferating and differentiating keratinocytes are electrically coupled, there are significant changes in the permeability properties of the junctions to small molecules. In parallel with the changes in gap junction protein expression during differentiation, the intercellular transfer of the small dyes neurobiotin, carboxyfluorescein, and Lucifer yellow is significantly reduced, whereas that of small metabolites, such as nucleotides and amino acids, proceeds unimpeded. Thus, a switch in gap junction protein expression in differentiating keratinocytes is accompanied by selective changes in junctional permeability that may play an important role in the coordinate control of the differentiation process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.