ArticleProceedings of the National Academy of Sciences of the United States of America1994
Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Differential Regulation ofJournal of pathogens · 2018Article
- Prebiotic Oligosaccharides Potentiate Host Protective Responses against L. Monocytogenes Infection.Pathogens (Basel, Switzerland) · 2017Article
- Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.PloS one · 2013Article
- Heat shock factor 1 protects against lung mycoplasma pneumoniae infection in mice.Journal of innate immunity · 2012Article
- Infection-related declines in chill coma recovery and negative geotaxis in Drosophila melanogaster.PloS one · 2012Article
- Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues.Infection and immunity · 2006Article
- Osmolarity and pH growth conditions regulate fim gene transcription and type 1 pilus expression in uropathogenic Escherichia coli.Infection and immunity · 2002Article
- Listeria pathogenesis and molecular virulence determinants.Clinical microbiology reviews · 2001Review
- Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene.Infection and immunity · 1997Article
- Differential regulation of cytokine and cytokine receptor mRNA expression upon infection of bone marrow-derived macrophages with Listeria monocytogenes.Infection and immunity · 1996Article
- Analysis of epithelial cell stress response during infection by Shigella flexneri.Infection and immunity · 1996Article
- Detection and characterization by differential PCR of host eukaryotic cell genes differentially transcribed following uptake of intracellular bacteria.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effect of Listeria monocytogenes infection of J774 macrophage-like mouse cells on induction of several stress genes, including genes for heat shock proteins (HSPs) and a protein-tyrosine phosphatase (PTP), to understand the host response in various steps of the bacterial invasion process. Exposure to wild-type L. monocytogenes strain EGD elicited an early induction of HSP70 mRNA with a corresponding early appearance of HSP70 protein. Cytochalasin D pretreatment prevented the induction of HSP70 mRNA in L. monocytogenes-infected macrophages. After a 2-hr infection with L. monocytogenes, PTP and to a lesser extent HSP90 mRNA levels were elevated. A listeriolysin-negative mutant of L. monocytogenes strain EGD and a noninvasive species of Listeria, Listeria innocua, did not induce PTP or HSP90 mRNA in infected macrophages. Mutations in other virulence genes did not affect transcription of PTP or HSP90. Expression of HSP60 mRNA remained constant over the time course studied in wild-type or mutant strains. These results suggest that phagocytosis of L. monocytogenes triggers transcription of HSP70 mRNA in macrophages; however, escape from the phagosome appears to be necessary for induction of PTP and HSP90 mRNA. Since both PTP and HSP90 may have links with signal transduction pathways in eukaryotic cells, the induction of these mRNAs suggests a role for L. monocytogenes in influencing the signal transduction routes of the host cell.
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