ArticleGene expression1993
Comparative utilization of transcription factor GABP by the promoters of ribosomal protein genes rpL30 and rpL32.
Article in Gene expression, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible.Molecular cell · 2025Article
- Regulation of ribosomal protein genes: An ordered anarchy.Wiley interdisciplinary reviews. RNA · 2021Review
- Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels.Biotechnology research international · 2011Article
- Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion.Nucleic acids research · 2009Article
- Regulation of the human SOX9 promoter by Sp1 and CREB.Experimental cell research · 2007Article
- The architecture of mammalian ribosomal protein promoters.BMC evolutionary biology · 2005Article
- Functional characterization of transcriptional regulatory elements in the upstream region and intron 1 of the human S6 ribosomal protein gene.The Biochemical journal · 1998Article
- Nuclear control of respiratory chain expression in mammalian cells.Journal of bioenergetics and biomembranes · 1997Review
- Binding of the Ets factor GA-binding protein to an upstream site in the factor IX promoter is a critical event in transactivation.Molecular and cellular biology · 1996Article
- A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.Molecular and cellular biology · 1995Article
- A novel transcriptional initiator activity of the GABP factor binding ets sequence repeat from the murine cytochrome c oxidase Vb gene.Gene expression · 1995Article
- Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The promoters of two mouse ribosomal protein genes, rpL30 and rpL32, contain a similarly located element, called beta, which was previously shown to interact with the same nuclear protein. This protein has now been identified as the GA-binding protein (GABP) on the basis of studies with recombinant GABP subunits and GABP-specific antibodies. The rpL30 element consists of two contiguous GABP binding sites that can form a tetrameric complex with two alpha and two beta 1 subunits of GABP, as well as dimeric complexes with alpha and either the beta 1 or beta 2 subunit. The rpL32 element consists of a solitary GABP binding site that can form only dimeric complexes with alpha and beta 1 or beta 2. Footprint analysis and a comparison of the effects of mutations in each of the tandem rpL30 binding sites demonstrated that the site nearest to the transcriptional start point is strongly favored for dimeric complex formation and is correspondingly more important for rpL30 promoter function. The contributions to overall promoter activity of the proximal rpL30 site and the solitary rpL32 site are virtually the same. Paradoxically, the potential for tetramer formation afforded by the tandem sites in rpL30 has a relatively minor effect on overall promoter strength. These findings illustrate the subtlety of mechanisms by which fine-tuning of rp promoters is achieved.
Indexed as
Identifiers
8019128PMC6081616W2413301893What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.