ReviewAnnals of hematology1994
Inadequate erythropoietin response to anemia: definition and clinical relevance.
Review in Annals of hematology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A minimal mathematical model of red blood cell homeostasis in anemia.PLoS computational biology · 2026Article
- The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study.Haematologica · 2015Observational
- Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia.Clinical and experimental medicine · 2011Article
- Article
- Quantitative analysis of mechanisms that govern red blood cell age structure and dynamics during anaemia.PLoS computational biology · 2009Article
- Antiviral therapy in hepatitis C virus cirrhotic patients in compensated and decompensated condition.World journal of gastroenterology · 2008Review
- Stimulating erythropoiesis in inflammatory bowel disease associated anemia.World journal of gastroenterology · 2007Review
- Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment.Annals of the rheumatic diseases · 2006Review
- Anemia and interleukin-10, tumor necrosis factor alpha, and erythropoietin levels among children with acute, uncomplicated Plasmodium falciparum malaria.Clinical and diagnostic laboratory immunology · 2001Article
- Should erythrocyte destruction in vivo be through phagocytosis alone?Journal of biosciences · 2000Article
- Anaemia in systemic lupus erythematosus: aetiological profile and the role of erythropoietin.Annals of the rheumatic diseases · 2000Article
- Serum erythropoietin level in anemic cancer patients.Medical oncology (Northwood, London, England) · 2000Article
- Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Nitric oxide donors suppress erythropoietin production in vitro.Pflugers Archiv : European journal of physiology · 1996Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of a specific and sensitive immunoassay for the measurement of serum erythropoietin (s-Epo) allows to improve our understanding of the model of in vivo regulation of erythropoiesis. In most anemias, circulating hemoglobin level determines Epo production which in turn stimulates erythropoietic activity. The disruption of the expected feedback mechanism of Epo production leads to an inadequately low s-Epo. The definition of inadequate Epo response to anemia relies on the documentation of a downregulated dependence of s-Epo on Hb with respect to the same dependence in patients with a physiologically regulated erythropoiesis. Literature reports a wide range of so called adequate s-Epo response to anemia and a number of criteria for judging on the adequateness of s-Epo at a certain degree of anemia. The O/P (observed/predicted) ratio allows categorization of each individual patient. The clinical syndromes in which an inadequate Epo response has been reported are numerous and the mechanisms of defective Epo production are different. A number of evidences clearly point to a relation between responsiveness to r-Hu-Epo and inadequate Epo response. This inequivocabily confirms the role inadequate Epo response plays in the pathogenesis of anemia.
Indexed as
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Registered trials
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