Evidence map›Paper›PMID 8016146›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1994

Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

F Périer, C M Radeke, C A Vandenberg

Open access · greenAbstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 140 citations in OpenAlex.

  1. DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  2. Article
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  4. Review
  5. Article
  6. Basolateral membrane K+ channels in renal epithelial cells.American journal of physiology. Renal physiology · 2012
    Review
  7. Article
  8. Cardiac strong inward rectifier potassium channels.Journal of molecular and cellular cardiology · 2010
    Review
  9. Article
  10. Molecular basis for genistein-induced inhibition of Kir2.3 currents.Pflugers Archiv : European journal of physiology · 2008
    Article
  11. Phosphoinositide-mediated gating of inwardly rectifying K(+) channels.Pflugers Archiv : European journal of physiology · 2007
    Review
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

F PérierDepartment of Biological Sciences, University of California, Santa Barbara 93106.
C M Radeke
C A Vandenberg
University of California, Santa Barbara · US

Funding

MOLECULAR PHYSIOLOGY OF CARDIAC POTASSIUM CHANNELSR01HL041656 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI VANDENBERG, CAROL A · 1996 to 2000
$221k
PHYSIOLOGY OF CARDIAC ION CHANNELSR29HL041656 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI VANDENBERG, CAROL A · 1989 to 1993
–
NHLBI NIH HHS HL41656
6 · The paper itself

Abstract

We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics. Single-channel recordings indicate that the HIR channel has an unusually small conductance (13 pS), distinguishing HIR from other cloned inward rectifiers. RNA blot analyses show that HIR transcripts are present in heart, skeletal muscle, and several different brain regions, including the hippocampus.

Indexed as

Amino Acid SequenceAnimalsBariumBase SequenceCesiumCloning, MolecularDNA, ComplementaryElectrophysiologyFemaleGene LibraryHippocampusHumansMembrane PotentialsMolecular Sequence DataOligonucleotide ProbesOocytesBariumCesiumDNA, ComplementaryOligonucleotide ProbesPotassium Channels

Identifiers

PMID8016146
PMCPMC44174
OpenAlexW2082549404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.