ArticleProceedings of the National Academy of Sciences of the United States of America1994
par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 87 citations in OpenAlex.
- Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity.The EMBO journal · 2024Article
- Mechanochemical Control of Symmetry Breaking in theFrontiers in cell and developmental biology · 2020Review
- Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Molecular biology of the cell · 2018Article
- PAR proteins regulate maintenance-phase myosin dynamics duringMolecular biology of the cell · 2017Article
- Influence of cell polarity on early development of the sea urchin embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo.PloS one · 2015Article
- A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Genetics · 2012Article
- Signaling pathways in cell polarity.Cold Spring Harbor perspectives in biology · 2012Article
- Polarization and myelination in myelinating glia.ISRN neurology · 2012Article
- Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.PLoS genetics · 2012Article
- Par proteins and neuronal polarity.Developmental neurobiology · 2011Review
- A survey of new temperature-sensitive, embryonic-lethal mutations in C. elegans: 24 alleles of thirteen genes.PloS one · 2011Article
- The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Development (Cambridge, England) · 2010Article
- Widely conserved signaling pathways in the establishment of cell polarity.Cold Spring Harbor perspectives in biology · 2009Review
- The PAR proteins: fundamental players in animal cell polarization.Developmental cell · 2007Review
- Article
- Stabilization of cell polarity by the C. elegans RING protein PAR-2.Developmental cell · 2006Article
- A genomewide survey of developmentally relevant genes in Ciona intestinalis. VII. Molecules involved in the regulation of cell polarity and actin dynamics.Development genes and evolution · 2003Article
- Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans.Genome biology · 2001Article
- The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.Genes & development · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The par-2 gene of Caenorhabditis elegans functions in early embryogenesis to ensure an asymmetric first cleavage and the segregation of cytoplasmic factors. Both processes appear to be required to generate daughter blastomeres with distinct developmental potential. We isolated an allele of par-2 by using a screen for maternal-effect lethal mutations in a strain known for its high frequency of transposition events. A transposable element was found to be linked to this allele. Sequences flanking the site of transposon insertion were cloned and found to rescue the par-2 mutant phenotype. DNA in the par-2 region hybridized to a 2.3-kb germ-line-enriched mRNA. The cDNA corresponding to this germ-line-enriched message was cloned, sequenced, and used to identify the molecular lesions associated with three par-2 alleles. Sequence analysis of the par-2 cDNA revealed that the predicted protein contained two distinct motifs found in other known proteins: an ATP-binding site and a cysteine-rich motif which identifies the par-2 gene product as a member of a growing class of putative zinc-binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.