ArticleProceedings of the National Academy of Sciences of the United States of America1994
N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 102 citations in OpenAlex.
- Global protein-ligand binding affinity profiling via photocatalytic labeling.Nature communications · 2026Article
- Bi-allelic variants in NRDC cause a neurodevelopmental disorder characterized by neonatal lethality, microcephaly, and brain abnormalities.American journal of human genetics · 2026Article
- Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.Kidney & blood pressure research · 2026Article
- Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle.Journal of sport and health science · 2025Article
- Conservation of OFD1 Protein Motifs: Implications for Discovery of Novel Interactors and the OFD1 Function.International journal of molecular sciences · 2025Article
- Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.Scientific reports · 2022Article
- Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.Scientific reports · 2017Article
- Article
- Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion.RMD open · 2017Article
- The Effects of Trivalent Lanthanide Cationization on the Electron Transfer Dissociation of Acidic Fibrinopeptide B and its Analogs.Journal of the American Society for Mass Spectrometry · 2016Article
- Ultrastructural localization and distribution of Nardilysin in mammalian male germ cells.Basic and clinical andrology · 2016Article
- The use of chromium(III) to supercharge peptides by protonation at low basicity sites.Journal of the American Society for Mass Spectrometry · 2015Article
- Critical roles of nardilysin in the maintenance of body temperature homoeostasis.Nature communications · 2014Article
- NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression.Cancer science · 2014Article
- A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3).The Biochemical journal · 2013Article
- The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor.Frontiers in endocrinology · 2013Article
- Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.EMBO molecular medicine · 2012Article
- Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.The Journal of biological chemistry · 2012Article
- Expression of type II chorionic gonadotropin genes supports a role in the male reproductive system.Molecular and cellular biology · 2011Article
- Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.Nature neuroscience · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-Arg dibasic convertase is a metalloendopeptidase from rat brain cortex and testis that cleaves peptide substrates on the N terminus of Arg residues in dibasic stretches. By using both an oligonucleotide and antibodies to screen a rat testis cDNA library, a full-length cDNA was isolated. The sequence contains an open reading frame of 1161 codons corresponding to a protein of 133 kDa that exhibits 35% and 48% similarity with Escherichia coli protease III (pitrilysin, EC 3.4.99.44) and rat or human insulinase (EC 3.4.99.45), respectively. Moreover, the presence of the HXXEH amino acid signature (XX = FL) clearly classifies N-Arg dibasic convertase as a member of the pitrilysin family of zinc-metalloendopeptidases. In addition, a Cys residue that may be responsible for the thiol sensitivity of the insulinase and N-Arg dibasic convertase was proposed. The protein sequence contains a distinctive additional feature consisting of a stretch of 71 acidic amino acids. We hypothesize that this metalloendopeptidase may be a member of a distinct class of processing enzymes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.