ArticleProceedings of the National Academy of Sciences of the United States of America1994
Protection of mice from endotoxic death by 2-methylthio-ATP.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 55 citations in OpenAlex.
- Physiologic roles of P2 receptors in leukocytes.Journal of leukocyte biology · 2022Review
- Purinergic and calcium signaling in macrophage function and plasticity.Frontiers in immunology · 2014Review
- Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages.Journal of leukocyte biology · 2013Article
- Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Extracellular nucleotides as negative modulators of immunity.Current opinion in pharmacology · 2009Review
- The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells.Journal of leukocyte biology · 2008Article
- Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.Immunology · 2007Article
- Nucleotide receptor signalling and the generation of reactive oxygen species.Purinergic signalling · 2007Article
- Shaping immune responses through the activation of dendritic cells' P2 receptors.Purinergic signalling · 2007Article
- Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammation.Neurochemical research · 2001Review
- Nuclear translocation of NF-kappaB in lipopolysaccharide-treated macrophages fails to correspond to endotoxicity: evidence suggesting a requirement for a gamma interferon-like signal.Infection and immunity · 1998Article
- Extracellular ATP activates calcium signaling, ion, and fluid transport in retinal pigment epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Apoptosis by 2-chloro-2'-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells.Neurochemistry internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The lethal effects of endotoxin, a bacterial product shed into the blood during bacteremia, are thought to be due to macrophage release of mediators such as tumor necrosis factor alpha and interleukin 1. Although much is known about the pathophysiology of endotoxemia, relatively little is known about the cellular signaling mechanisms that are involved. The data in this study suggest that extracellular adenine nucleotides can influence the development of endotoxin shock. An adenine nucleotide analog, 2-methylthio-ATP, inhibited the endotoxin-stimulated release of toxic mediators (i.e., tumor necrosis factor alpha and interleukin 1), and it protected mice from endotoxin-induced death. These studies suggest a fundamental and unusual role for adenine nucleotides on endotoxin action, and they provide a potentially new therapeutic approach for the control of the pathophysiology of Gram-negative septicemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.