ArticleProceedings of the National Academy of Sciences of the United States of America1994
Evolutionary selection against change in many Alu repeat sequences interspersed through primate genomes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- DISCOVER: a feature-based discriminative method for motif search in complex genomes.Bioinformatics (Oxford, England) · 2009Article
- The evolution of mobile DNAs: when will transposons create phylogenies that look as if there is a master gene?Genetics · 2006Article
- Alu elements contain many binding sites for transcription factors and may play a role in regulation of developmental processes.BMC genomics · 2006Article
- Evolution and distribution of RNA polymerase II regulatory sites from RNA polymerase III dependant mobile Alu elements.BMC evolutionary biology · 2004Article
- The mammalian transcriptome and the function of non-coding DNA sequences.Genome biology · 2004Review
- V-SINEs: a new superfamily of vertebrate SINEs that are widespread in vertebrate genomes and retain a strongly conserved segment within each repetitive unit.Genome research · 2002Article
- Schistosome satellite DNA encodes active hammerhead ribozymes.Molecular and cellular biology · 1998Article
- Alu evolution in human populations: using the coalescent to estimate effective population size.Genetics · 1997Article
- DNA sequence insertion and evolutionary variation in gene regulation.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Regional localization of human M-BCR gene to chromosome 23 band q11 in the great apes.Genetica · 1996Article
- A population genetic study of the evolution of SINEs. II. Sequence evolution under the master copy model.Genetics · 1996Article
- Randomness and degrees of irregularity.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Increased concentration of some transcription factor binding sites in human retroposons of the Alu family.Genetica · 1996Article
- The age of Alu subfamilies.Journal of molecular evolution · 1996Article
- The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Evidence that most human Alu sequences were inserted in a process that ceased about 30 million years ago.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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Abstract
Mutations have been examined in the 1500 interspersed Alu repeats of human DNA that have been sequenced and are nearly full length. There is a set of particular changes at certain positions that rarely occur (termed suppressed changes) compared to the average of identical changes of identical nucleotides in the rest of the sequence. The suppressed changes occur in positions that are clustered together in what appear to be sites for protein binding. There is a good correlation of the suppression in different positions, and therefore the joint probability of absence of mutation at many pairs of such positions is significantly higher than that expected at random. The suppression of mutation appears to result from selection that is not due to requirements for Alu sequence replication. The implication is that hundreds of thousands of Alu sequences have sequence-dependent functions in the genome that are selectively important for primates. In a few known cases Alu inserts have been adapted to function in the regulation of gene transcription.
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