ArticleProceedings of the National Academy of Sciences of the United States of America1994
Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
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Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Analysis of two-locus traits under heterogeneity for recessive versus dominant inheritance.Genetic epidemiology · 1997Trial
- The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders.Genes · 2023Review
- Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci.Translational psychiatry · 2019Article
- A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.Journal of cellular and molecular medicine · 2017Article
- Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.PLoS genetics · 2014Article
- Dyslexia: the Role of Vision and Visual Attention.Current developmental disorders reports · 2014Review
- Chromosome 18p11.2 harbors susceptibility marker: D18S452, for bipolar affective disorder.Indian journal of psychiatry · 2013Article
- Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series.Bipolar disorders · 2012Article
- Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.PloS one · 2012Article
- Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2010Article
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.Neuroscience and biobehavioral reviews · 2010Review
- Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Lithium: a key to the genetics of bipolar disorder.Genome medicine · 2009Article
- Association study on the mitochondrial gene NDUFV2 and bipolar disorder in the Chinese Han population.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder.Schizophrenia bulletin · 2008Review
- Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission.Molecular psychiatry · 2007Article
- Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.Molecular psychiatry · 2005Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
In the course of a systematic genomic survey, 22 manic-depressive (bipolar) families were examined for linkage to 11 chromosome 18 pericentromeric marker loci, under dominant and recessive models. Overall logarithm of odds score analysis for the pedigree series was not significant under either model, but several families yielded logarithm of odds scores consistent with linkage under dominant or recessive models. Affected sibling pair analysis of these data yielded evidence for linkage (P < 0.001) at D18S21. Affected pedigree member analysis also suggests linkage, with multilocus results for five loci giving P < 0.0001 and P = 0.0007 for weighting functions f(p) = 1 and 1/square root p, respectively, where p is the allele frequency. These results imply a susceptibility gene in the pericentromeric region of chromosome 18, with a complex mode of inheritance. Two plausible candidate genes, a corticotropin receptor and the alpha subunit of a GTP binding protein, have been localized to this region.
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