ArticlePflugers Archiv : European journal of physiology1994
Synergistic action of histamine and adenosine triphosphate on the response to noradrenaline in rabbit pulmonary artery smooth muscle cells.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle.Frontiers in physiology · 2021Review
- The bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth muscles.Channels (Austin, Tex.) · 2014Review
- Signalling pathway for histamine activation of non-selective cation channels in equine tracheal myocytes.The Journal of physiology · 2000Article
- Release of Ca2+ from intracellular store in smooth muscle cells of rat portal vein by ATP-induced Ca2+ entry.British journal of pharmacology · 1994Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The interaction between histamine, adenosine triphosphate (ATP) and noradrenaline was studied with the perforated-patch technique in single cells isolated from the rabbit pulmonary artery. In these cells all of the agents activated caffeine-sensitive currents. In potassium-free conditions at a holding potential of -50 mV bath applied histamine, in concentrations that did not produce a response, greatly enhanced the magnitude of inward currents evoked by ionophoretic application of noradrenaline. These inward currents were calcium-activated chloride currents, ICl(Ca). In potassium-containing solutions at a holding potential of 0 mV, bath applied histamine potentiated the outward currents (calcium-activated potassium currents (IK(Ca)) induced by noradrenaline. This synergistic action was rapid in onset, sustained during the continued presence of histamine and reversible. Bath application of noradrenaline inhibited the response to ionophoretically applied noradrenaline but not the caffeine-induced currents. ATP also stimulated ICl(Ca) and IK(Ca) through a mechanism dependent on the caffeine-sensitive intracellular calcium store and also potentiated the currents activated by noradrenaline. It is concluded that one explanation for the phenomenon of potentiation in smooth muscle is convergence of several distinct pharmacological receptors to a common cellular mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.