ArticleThe EMBO journal1994
The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 115 citations in OpenAlex.
- Calcineurin Regulates Conidiation, Chlamydospore Formation and Virulence inFrontiers in microbiology · 2020Article
- The transcription factor FgCrz1A is essential for fungal development, virulence, deoxynivalenol biosynthesis and stress responses in Fusarium graminearum.Current genetics · 2019Article
- Combining ChIP-chip and expression profiling to model the MoCRZ1 mediated circuit for Ca/calcineurin signaling in the rice blast fungus.PLoS pathogens · 2010Article
- Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.Eukaryotic cell · 2008Article
- Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.Eukaryotic cell · 2006Article
- Aspergillus infections in transplant recipients.Clinical microbiology reviews · 2005Review
- Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.Molecular biology of the cell · 2004Article
- A Magnaporthe grisea cyclophilin acts as a virulence determinant during plant infection.The Plant cell · 2002Article
- Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.The EMBO journal · 2001Article
- Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.The EMBO journal · 2000Article
- Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.Antimicrobial agents and chemotherapy · 2000Article
- Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.Infection and immunity · 2000Article
- Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.Clinical microbiology reviews · 1999Review
- pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast.The EMBO journal · 1998Article
- Calcineurin is required for virulence of Cryptococcus neoformans.The EMBO journal · 1997Article
- Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.Molecular biology of the cell · 1996Article
- Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts.The Biochemical journal · 1996Article
- vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.Genetics · 1995Article
- Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.The EMBO journal · 1995Article
- Phosphorylation of rat liver heterogeneous nuclear ribonucleoproteins A2 and C can be modulated by calmodulin.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene encoding the homologue of the catalytic subunit of the Ca2+/calmodulin-regulated protein phosphatase 2B (calcineurin A) has been isolated from Aspergillus nidulans. This gene, cnaA+, is essential in this fungal system. Analysis of growth-arrested cells following gene disruption by homologous recombination reveals that they are blocked early in the cell cycle. The cnaA+ gene encodes a 2.5 kb mRNA and the deduced protein sequence is highly homologous to the calcineurin A subunit of other species. The mRNA varies in a cell cycle-dependent manner with maximal levels found early in G1 and considerably before the G1/S boundary. As calmodulin is also essential for A.nidulans cell cycle progression and levels rise before the G1/S boundary, our data suggest that calcineurin may represent a primary target for calmodulin at this cell cycle transition point.
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Registered trials
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