ArticleMammalian genome : official journal of the International Mammalian Genome Society1994
Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Article
- Association in a Chinese population of a genetic variation in the early B-cell factor 1 gene with coronary artery disease.BMC cardiovascular disorders · 2017Observational
- Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.Genes & development · 2016Article
- Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes.Journal of leukocyte biology · 2015Article
- Gene coexpression measures in large heterogeneous samples using count statistics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression.PloS one · 2014Article
- Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.The Journal of biological chemistry · 2013Article
- Regulation of early adipose commitment by Zfp521.PLoS biology · 2012Article
- The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers.Molecular and cellular biology · 2002Review
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4 authors at 2 institutions in 1 country.
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Abstract
Murine B lymphocytes, adipocytes, and olfactory neurons contain a DNA-binding protein that participates in the regulation of genes encoding tissue-specific components of signal transduction. Purification and cloning of this protein, termed early B-cell factor (EBF), from murine B lymphocytes and independent cloning of a protein, termed Olf-1, from olfactory neuronal cells revealed virtual complete amino acid sequence identity between these proteins. As a first step towards identifying a human genetic disorder or mouse mutation for which EBF could be a candidate gene, we have chromosomally mapped the corresponding locus in both species. By Southern hybridization analyses of somatic cell hybrid panels with murine cDNA probe, fluorescence chromosomal in situ hybridization (FISH) of human genomic clones, and analysis of recombinant inbred mouse strains, we have found single sites for EBF homologous sequences on human Chromosome (Chr) 5, band q34, and on proximal mouse Chr 11, in an evolutionarily conserved region.
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