ArticleBiophysical journal1994
Theory for measuring bivalent surface binding kinetics using total internal reflection with fluorescence photobleaching recovery.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Review
- Total internal reflection with fluorescence correlation spectroscopy: nonfluorescent competitors.Biophysical journal · 2004Article
- Total internal reflection with fluorescence correlation spectroscopy: combined surface reaction and solution diffusion.Biophysical journal · 2001Article
- Theory for ligand rebinding at cell membrane surfaces.Biophysical journal · 1998Article
- Mapping fluorophore distributions in three dimensions by quantitative multiple angle-total internal reflection fluorescence microscopy.Biophysical journal · 1997Article
- Cytoplasmic viscosity near the cell plasma membrane: translational diffusion of a small fluorescent solute measured by total internal reflection-fluorescence photobleaching recovery.Biophysical journal · 1996Article
- Kinetics of ligand binding to receptor immobilized in a polymer matrix, as detected with an evanescent wave biosensor. I. A computer simulation of the influence of mass transport.Biophysical journal · 1996Article
- New dimensions in two dimensions.Biophysical journal · 1994Article
- Translational diffusion of bovine prothrombin fragment 1 weakly bound to supported planar membranes: measurement by total internal reflection with fluorescence pattern photobleaching recovery.Biophysical journal · 1994Article
- Total internal reflection fluorescence microscopy: application to substrate-supported planar membranes.European biophysics journal : EBJ · 1993Review
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Authors and funding
2 authors.
Funding
Abstract
Total internal reflection with fluorescence photobleaching recovery (TIR-FPR) is a method for experimentally examining coupled diffusion and reaction kinetics at surfaces. In a previous work (Thompson et al. 1981. Biophys. J. 33:435-454), a theoretical basis for interpreting TIR-FPR data was described for monovalent ligands that undergo a reversible reaction with monovalent surface sites in a single step. Here, the theory for TIR-FPR has been extended to two different surface binding mechanisms that involve sequential, bivalent surface attachment. Methods for obtaining the intrinsic surface association and dissociation kinetic rates from measured fluorescence photobleaching recovery curves are described. The new theory should be applicable to the association of bivalent protein ligands such as antibodies with supported planar model membranes.
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Registered trials
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