ArticleMolecular and cellular biology1994
The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 72 citations in OpenAlex.
- Sphingolipid accumulation causes mitochondrial dysregulation and cell death.Cell death and differentiation · 2017Article
- Complex regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA in Saccharomyces cerevisiae: experimental and computational evidences.BMC systems biology · 2015Article
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- The yeast Hot1 transcription factor is critical for activating a single target gene, STL1.Molecular biology of the cell · 2015Article
- Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae.Biochimica et biophysica acta · 2008Article
- The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output.Genes & development · 2007Article
- Regulation of respiratory growth by Ras: the glyoxylate cycle mutant, cit2Delta, is suppressed by RAS2.Current genetics · 2006Article
- Article
- Heat shock proteins as emerging therapeutic targets.British journal of pharmacology · 2005Review
- Article
- Shared and independent roles for a Galpha(i) protein and adenylyl cyclase in regulating development and stress responses in Neurospora crassa.Eukaryotic cell · 2002Article
- Anatomical analysis of Saccharomyces cerevisiae stalk-like structures reveals spatial organization and cell specialization.Journal of bacteriology · 2001Article
- AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation.Molecular and cellular biology · 2001Article
- RSK2 represses HSF1 activation during heat shock.Cell stress & chaperones · 2000Article
- Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1.The EMBO journal · 2000Article
- The yeast ras/cyclic AMP pathway induces invasive growth by suppressing the cellular stress response.Molecular and cellular biology · 1999Article
- Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway.The EMBO journal · 1998Article
- Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation.The EMBO journal · 1998Article
- Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae.Journal of bacteriology · 1998Article
- SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription.Molecular and cellular biology · 1995Article
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4 authors at 1 institution in 1 country.
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Abstract
Yeast strains in which the Ras-cyclic AMP (cAMP) pathway is constitutively active are sensitive to heat shock, whereas mutants in which the activity of this pathway is low are hyperresistant to heat shock. To determine the molecular basis for these differences, we examined the transcriptional induction of heat shock genes in various yeast strains. Activation of heat shock genes was attenuated in the strains in which the Ras-cAMP pathway is constitutively active. In contrast, in a strain deficient in cAMP production, several heat shock genes were induced by removal of cAMP from the medium. These results indicate that the Ras-cAMP pathway affects the induction of heat shock genes. In all of the mutants, heat shock transcription factor expression and activity were identical to those in wild-type cells. The response to heat shock in Ha-ras-transformed rat fibroblasts was also studied. While no induction of Hsp68 was observed in Ha-ras-transformed cells, proper regulation of heat shock transcription factor was found. Therefore, in mammals, as in Saccharomyces cerevisiae, the Ras pathway controls the transcription of heat shock genes via a mechanism not involving the heat shock transcription factor.
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