ArticleMolecular and cellular biology1994
Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 97 citations in OpenAlex.
- Tensile Forces and Nanofiber Alignment Influence Both Innervated and Non-Innervated Skeletal Myofiber Formation in Custom Mechanobioreactors.Biotechnology journal · 2025Article
- The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.Cells · 2023Review
- Article
- FOXG1 sequentially orchestrates subtype specification of postmitotic cortical projection neurons.Science advances · 2022Article
- The Function of FoxK Transcription Factors in Diseases.Frontiers in physiology · 2022Review
- Foxk1 regulates cancer progression.Annals of translational medicine · 2020Article
- FOXK1 promotes glioblastoma proliferation and metastasis through activation of Snail transcription.Experimental and therapeutic medicine · 2018Article
- FOXK1 interaction with FHL2 promotes proliferation, invasion and metastasis in colorectal cancer.Oncogenesis · 2016Article
- Direct regulation of FOXK1 by C-jun promotes proliferation, invasion and metastasis in gastric cancer cells.Cell death & disease · 2016Article
- Regulation of myoglobin expression.The Journal of experimental biology · 2010Review
- Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- FoxK mediates TGF-beta signalling during midgut differentiation in flies.The Journal of cell biology · 2008Article
- Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene.Journal of neurochemistry · 2008Article
- Sp3 proteins negatively regulate beta myosin heavy chain gene expression during skeletal muscle inactivity.Molecular and cellular biology · 2004Article
- Isolation and developmental expression of Xenopus FoxJ1 and FoxK1.Development genes and evolution · 2004Article
- 1H, 15N and 13C resonance assignments for the DNA-binding domain of myocyte nuclear factor (Foxk1).Journal of biomolecular NMR · 2002Article
- The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B.The Biochemical journal · 2000Article
- Article
- Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements.Molecular and cellular biology · 1999Article
- The human pH aldolase A promoter directs widespread but muscle-predominant expression in transgenic mice.Transgenic research · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A sequence motif (CCAC box) within an upstream enhancer region of the human myoglobin gene is essential for transcriptional activity in both cardiac and skeletal muscle. A cDNA clone, myocyte nuclear factor (MNF), was isolated from a murine expression library on the basis of sequence-specific binding to the myoglobin CCAC box motif and was found to encode a novel member of the winged-helix or HNF-3/fork head family of transcription factors. Probes based on this sequence identify two mRNA species that are upregulated during myocyte differentiation, and antibodies raised against recombinant MNF identify proteins of approximately 90, 68, and 65 kDa whose expression is regulated following differentiation of myogenic cells in culture. In addition, the 90-kDa form of MNF is phosphorylated and is upregulated in intact muscles subjected to chronic motor nerve stimulation, a potent stimulus to myoglobin gene regulation. Amino acid residues 280 to 389 of MNF demonstrate 35 to 89% sequence identity to the winged-helix domain from other known members of this family, but MNF is otherwise divergent. A proline-rich amino-terminal region (residues 1 to 206) of MNF functions as a transcriptional activation domain. These studies provide the first evidence that members of the winged-helix family of transcription factors have a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.