ArticleThe Journal of physiology1994
GABAergic and glutamatergic synaptic input to identified granule cells in salamander olfactory bulb.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Modulation of Neural Microcircuits That Control Complex Dynamics in Olfactory Networks.Frontiers in cellular neuroscience · 2021Article
- A coupled-oscillator model of olfactory bulb gamma oscillations.PLoS computational biology · 2017Article
- Regulation and Possible Functions of Kisspeptin in the Medial Amygdala.Frontiers in endocrinology · 2017Review
- The Diversity of Spine Synapses in Animals.Neuromolecular medicine · 2016Review
- Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice.Nature communications · 2015Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sparse distributed representation of odors in a large-scale olfactory bulb circuit.PLoS computational biology · 2013Article
- Article
- Dendritic action potentials connect distributed dendrodendritic microcircuits.Journal of computational neuroscience · 2008Article
- Branch-specific Ca2+ influx from Na+-dependent dendritic spikes in olfactory granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Chemosensory selectivity of output neurons innervating an identified, sexually isomorphic olfactory glomerulus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Contribution of a calcium-activated non-specific conductance to NMDA receptor-mediated synaptic potentials in granule cells of the frog olfactory bulb.The Journal of physiology · 2002Article
- Organization of ionotropic glutamate receptors at dendrodendritic synapses in the rat olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Multiple and opposing roles of cholinergic transmission in the main olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- The role of inhibition in an associative memory model of the olfactory bulb.Journal of computational neuroscience · 1997Article
- Optical imaging of spatiotemporal patterns of glutamatergic excitation and GABAergic inhibition in the guinea-pig auditory cortex in vivo.The Journal of physiology · 1996Article
- Investigation of the role of interneurons and their modulation by centrifugal fibers in a neural model of the olfactory bulb.Journal of computational neuroscience · 1996Article
- Effects of dopamine and fluphenazine on field potential amplitude in the salamander olfactory bulb.Experimental brain research · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell patch clamp recording techniques were applied to granule cells in an in vitro salamander olfactory bulb preparation to study their morphology, membrane properties and pharmacology of postsynaptic responses to electrical stimulation of either the olfactory nerve (ON) or medial olfactory tract (MOT). Optical recordings of the same preparations stained with the voltage-sensitive dye RH414 were also made. 2. Anatomical reconstructions of biocytin-filled granule cells showed that they extend widespread spine-bearing dendrites and an axon-like process that branched within the external plexiform layer. 3. ON or MOT stimulation evoked a long-lasting depolarization, usually generating only a single action potential, in granule cells studied under standard recording conditions. Bath application of bicuculline methiodide (BMI, a GABAA receptor antagonist, 20 or 25 microM) enhanced the spontaneous and electrically evoked excitatory drive to granule cells. 4. The electrically evoked synaptic responses consisted of both excitatory and inhibitory synaptic inputs. Using symmetrical Cl- conditions inside and outside the cell to enhance Cl- currents, spontaneous and electrically driven BMI-sensitive inhibitory postsynaptic currents (IPSCs) were revealed, indicating that granule cells receive GABAergic synaptic input. 5. Bath application of GABA (250 microM to 1 mM) shunted and hyperpolarized granule cells as observed directly from whole-cell recordings and indirectly from cell-attached patch single channel recordings. 6. Bath application of the glutamate receptor antagonists 6-cyano-2,3-dihydroxy-7-nitroquinoxaline (CNQX, 10 microM) and/or DL-2-amino-5-phosphonopentanoic acid (DL-AP5, 100 microM) showed that granule cell dendrodendritic EPSPs are shaped by both non-NMDA and NMDA receptors. 7. The time course and pharmacological sensitivity of both single granule cell responses and ensemble responses recorded optically in the deeper layers of the bulb correlated well. 8. It is concluded that salamander granule cells integrate several types of synaptic input, may have both dendritic and axonal output, and play a major role in generating voltage-sensitive dye signals in the olfactory bulb.
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