ArticleThe Journal of experimental medicine1994
The V delta 1 T cell receptor repertoire in human small intestine and colon.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 99 citations in OpenAlex.
- Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Cancer immunotherapy by γδ T cells.Science (New York, N.Y.) · 2024Review
- Immune Regulatory Networks and Therapy of γδ T Cells in Liver Cancer: Recent Trends and Advancements.Journal of clinical and translational hepatology · 2024Review
- CD1 and MR1 recognition by human γδ T cells.Molecular immunology · 2021Article
- Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease.Mucosal immunology · 2020Article
- Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection.Frontiers in immunology · 2020Article
- ORAI1 mutations abolishing store-operated CaThe Journal of allergy and clinical immunology · 2018Article
- Lymphadenopathy driven by TCR-VBlood advances · 2017Article
- Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection.Nature immunology · 2017Article
- Elevation of Vδ1 T cells in peripheral blood and livers of patients with primary biliary cholangitis.Clinical and experimental immunology · 2016Article
- Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.Frontiers in immunology · 2015Review
- Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.Immunity · 2013Article
- Potential regulatory role of in vitro-expanded Vδ1 T cells from human peripheral blood.Immunologic research · 2013Article
- Intraepithelial lymphocytes in celiac disease immunopathology.Seminars in immunopathology · 2012Review
- Human gamma delta T cells: candidates for the development of immunotherapeutic strategies.Immunologic research · 2007Review
- Shared reactivity of V{delta}2(neg) {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells.The Journal of experimental medicine · 2005Article
- Induction of T cell alertness by bacterial colonization of intestinal epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2002Review
- Prevalence of an ulcerative colitis-associated CD8+ T cell receptor beta-chain CDR3-region motif and its association with disease activity.Journal of clinical immunology · 2001Article
- Human gamma delta T lymphocytes in HIV disease: effector functions and control by natural killer cell receptors.Springer seminars in immunopathology · 2000Review
- Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
V delta 1 bearing T cells comprise the major population of gamma/delta T cells in the human intestinal tract. To gain insight into mechanisms involved in the generation of these cells and the diversity of their repertoire, we have characterized the junctional sequences of V delta 1 T cell receptor transcripts in the human small intestine and colon. Mucosal biopsies obtained from defined regions along the length of the small intestine or colon contained a high frequency of either one or a few identical in frame V delta 1 sequences. Less abundant sequences were also detected repeatedly throughout the length of small intestine or colon. Moreover, the intestinal V delta 1 repertoire in the small intestine and colon appeared compartmentalized and showed no overlap with the V delta 1 repertoire in peripheral blood. Dominant V delta 1 transcripts in each subject differed between the small intestine and colon, and the dominant transcripts within these sites differed among individuals. Analysis of small intestinal transcripts obtained at a 1-yr interval revealed that the V delta 1 repertoire was stable over time. The fact that the majority of V delta 1 transcripts, both dominant and rare, are distributed throughout a several meter length of the adult intestinal tract and are stable over time suggests they are not generated by an ongoing process of in situ VDJ gene rearrangement. Our results favor a model in which the repertoire of V delta 1 T cells in the intestinal tract is shaped by positive selection in response to a limited array of ligands before the migration of V delta 1 cells throughout the small intestine or colon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.