ArticleInfection and immunity1994
Listeria monocytogenes infection enhances transcription factor NF-kappa B in P388D1 macrophage-like cells.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Invasive phenotype of Candida albicans affects the host proinflammatory response to infection.Infection and immunity · 2005Article
- Relative importance of NF-kappaB p50 in mycobacterial infection.Infection and immunity · 2001Article
- Listeria pathogenesis and molecular virulence determinants.Clinical microbiology reviews · 2001Review
- Involvement of protein kinase C in Rickettsia rickettsii-induced transcriptional activation of the host endothelial cell.Infection and immunity · 1999Article
- Review
- Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression.Infection and immunity · 1999Article
- Bacterial invasion is not required for activation of NF-kappaB in enterocytes.Infection and immunity · 1999Article
- NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Bidirectional signaling between Yersinia and its target cell.Folia microbiologica · 1998Review
- Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene.Infection and immunity · 1997Article
- Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines.The Journal of experimental medicine · 1997Article
- Rickettsia rickettsii infection of cultured human endothelial cells induces NF-kappaB activation.Infection and immunity · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we investigated the effect of Listeria monocytogenes infection on the cellular level of the transcription factors NF-kappa B, AP-1, and NF-IL6 in the macrophage-like cell line P388D1 by using electrophoretic mobility shift assays. Infection with L. monocytogenes enhanced the formation of two NF-kappa B-like DNA-protein complexes, C1 and C2, whereas the concentration of AP-1 and NF-IL6 complexes remained unaffected. In supershift assays using NF-kappa B-specific antibodies, complex C2 was identified to be a p50 homodimer (KBF1) and complex C1 was identified as a p50/p65 heterodimer. Both complexes were formed within 10 min after addition of the bacteria. Since the synthesis of tumor necrosis factor alpha and interleukin-1 occurs at later times, these cytokines cannot be the mediators of enhanced NF-kappa B formation. Infection experiments with different nonhemolytic mutants of L. monocytogenes and the use of the phagocytosis inhibitor cytochalasin B suggest that events prior to invasion and escape of the bacteria from the phagosome into the cytoplasm enhance the nuclear transport of p50/p65 NF-kappa B components.
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