ArticleHuman genetics1994
Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci.
Article in Human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 71 citations in OpenAlex.
- Small hepatitis B virus surface antigen (SHBs) induces dyslipidemia by suppressing apolipoprotein-AII expression through ER stress-mediated modulation of HNF4α and C/EBPγ.Journal of virology · 2024Article
- Comparative Proteomic Study of the Antiproliferative Activity of Frog Host-Defence Peptide Caerin 1.9 and Its Additive Effect with Caerin 1.1 on TC-1 Cells Transformed with HPV16 E6 and E7.BioMed research international · 2018Article
- Metabolism of apolipoprotein A-II containing triglyceride rich ApoB lipoproteins in humans.Atherosclerosis · 2015Article
- Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris.Assay and drug development technologies · 2013Article
- Characteristics of metabolic syndrome based on clustering pattern among Korean adolescents: findings from the Korean National Health and Nutrition Examination Survey, 2007-2008.European journal of pediatrics · 2013Article
- Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population.Journal of Zhejiang University. Science. B · 2012Article
- Article
- Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23.American journal of human genetics · 2000Article
- A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels.The Journal of clinical investigation · 1996Article
- Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.The Journal of clinical investigation · 1996Article
- Multilocus genetic determinants of LDL particle size in coronary artery disease families.American journal of human genetics · 1996Article
- Sex difference in the regulation of plasma high density lipoprotein cholesterol by genetic and environmental factors.Human genetics · 1996Article
- Article
- Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins.Journal of clinical lipidologyArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
We have tested for evidence of linkage between the genetic loci determining concentrations and composition of plasma high density lipoproteins (HDL) with the genes for the major apolipoproteins and enzymes participating in lipoprotein metabolism. These genes include those encoding various apolipoproteins (apo), including apoA-I, apoA-II, apoA-IV, apoB, apoC-I, apoC-II, apoC-III, apoE, and apo(a), cholesteryl ester transfer protein (CETP), HDL-binding protein, lipoprotein lipase, and the low density lipoprotein (LDL) receptor. Polymorphisms of these genes, and nearby highly polymorphic simple sequence repeat markers, were examined by quantitative sib-pair linkage analysis in 30 coronary artery disease families consisting of a total of 366 individuals. Evidence for linkage was observed between a marker locus D16S313 linked to the CETP locus and a locus determining plasma HDL-cholesterol concentration (P = 0.002), and the genetic locus for apoA-II and a locus determining the levels of the major apolipoproteins of HDL, apoA-I and apoA-II (P = 0.009 and 0.02, respectively). HDL level was also influenced by the variation at the apo(a) locus on chromosome 6 (P = 0.02). Thus, these data indicate the simultaneous involvement of at least two different genetic loci in the determination of the levels of HDL and its associated lipoproteins.
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