ArticleGenetics1994
Double or nothing: a Drosophila mutation affecting meiotic chromosome segregation in both females and males.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Prolonged ovarian storage of matureeLife · 2019Article
- Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes.Genetics · 2016Article
- Drosophila BubR1 is essential for meiotic sister-chromatid cohesion and maintenance of synaptonemal complex.Current biology : CB · 2007Article
- Misregulation of the kinesin-like protein Subito induces meiotic spindle formation in the absence of chromosomes and centrosomes.Genetics · 2007Article
- Genome-wide redistribution of meiotic double-strand breaks in Saccharomyces cerevisiae.Molecular and cellular biology · 2007Article
- The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes.Molecular biology of the cell · 2005Article
- Association between maternal age and meiotic recombination for trisomy 21.American journal of human genetics · 2005Article
- Isolation and cytogenetic characterization of male meiotic mutants of Drosophila melanogaster.Genetics · 2004Article
- A function for subtelomeric DNA in Saccharomyces cerevisiae.Genetics · 2003Article
- Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.Genetics · 2000Article
- Analysis of aneuploidy frequencies in sperm from patients with hereditary nonpolyposis colon cancer and an hMSH2 mutation.American journal of human genetics · 2000Article
- Review
- Article
- Meiotic chromosome dynamics dependent upon the rec8(+), rec10(+) and rec11(+) genes of the fission yeast Schizosaccharomyces pombe.Genetics · 1999Article
- Article
- Use of a recombination reporter insert to define meiotic recombination domains on chromosome III of Saccharomyces cerevisiae.Molecular and cellular biology · 1999Article
- Conservation of the centromere/kinetochore protein ZW10.The Journal of cell biology · 1997Article
- Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.The Journal of cell biology · 1996Article
- Exchanges are not equally able to enhance meiotic chromosome segregation in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Meiosis in Drosophila: seeing is believing.Proceedings of the National Academy of Sciences of the United States of America · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a Drosophila mutation, Double or nothing (Dub), that causes meiotic nondisjunction in a conditional, dominant manner. Previously isolated mutations in Drosophila specifically affect meiosis either in females or males, with the exception of the mei-S332 and ord genes which are required for proper sister-chromatid cohesion. Dub is unusual in that it causes aberrant chromosome segregation almost exclusively in meiosis I in both sexes. In Dub mutant females both nonexchange and exchange chromosomes undergo nondisjunction, but the effect of Dub on nonexchange chromosomes is more pronounced. Dub reduces recombination levels slightly. Multiple nondisjoined chromosomes frequently cosegregate to the same pole. Dub results in nondisjunction of all chromosomes in meiosis I of males, although the levels are lower than in females. When homozygous, Dub is a conditional lethal allele and exhibits phenotypes consistent with cell death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.