ArticleClinical and experimental immunology1994
Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
- Assessment of interferon-γ levels and leishmanin skin test results in persons recovered for leishmaniasis.The American journal of tropical medicine and hygiene · 2012Trial
- Immunoinformatic Analysis ofRecent advances in inflammation & allergy drug discovery · 2024Article
- Memory T cells: promising biomarkers for evaluating protection and vaccine efficacy against leishmaniasis.Frontiers in immunology · 2024Review
- Possibilities and challenges for developing a successful vaccine for leishmaniasis.Parasites & vectors · 2016Review
- Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production.PloS one · 2016Article
- Epidemiology of visceral leishmaniasis in Georgia.PLoS neglected tropical diseases · 2014Article
- An evolutionary analysis of trypanosomatid GP63 proteases.Parasitology research · 2011Article
- CD26 expression on CD4+T cells in patients with cutaneous leishmaniasis.Clinical and experimental immunology · 2008Article
- Mononuclear cells from patients recovered from cutaneous leishmaniasis respond to Leishmania major amastigote class I nuclease with a predominant Th1-like response.Clinical and experimental immunology · 2005Article
- Diagnostic techniques to detect cryptic leishmaniasis in dogs.Clinical and diagnostic laboratory immunology · 2002Article
- Comparison of the immune profile of nonhealing cutaneous Leishmaniasis patients with those with active lesions and those who have recovered from infection.Infection and immunity · 2000Article
- Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis.Clinical and experimental immunology · 1999Article
- Leishmanin skin test lymphoproliferative responses and cytokine production after symptomatic or asymptomatic Leishmania major infection in Tunisia.Clinical and experimental immunology · 1999Article
- Indications of the protective role of natural killer cells in human cutaneous leishmaniasis in an area of endemicity.Infection and immunity · 1998Article
- Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production.Infection and immunity · 1997Article
- Leishmania and human immunodeficiency virus coinfection: the first 10 years.Clinical microbiology reviews · 1997Review
- Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections.Clinical and experimental immunology · 1995Article
- Antigen-presenting cells in human cutaneous leishmaniasis due to Leishmania major.Clinical and experimental immunology · 1995Article
- Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients.Clinical and experimental immunology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T cell response to antigens from Leishmania major promastigotes was investigated in peripheral blood mononuclear cells from Sudanese individuals with a history of cutaneous leishmaniasis (CL), Sudanese individuals with positive DTH reaction in the leishmanin skin test but with no history of skin lesions, and in Danes without known exposure to Leishmania parasites. Proliferation and production of interferon-gamma (IFN-gamma) and IL-4 in antigen-stimulated cultures was measured. Lymphocytes from individuals with a history of CL proliferated vigorously and produced IFN-gamma after stimulation with either a crude preparation of L. major antigens or the major surface protease gp63. These cultures produced no or only little IL-4. Also cells from leishmanin skin test-positive donors with no history of CL produced IFN-gamma and no IL-4 in response to L. major antigens. Cells from the unexposed Danes were not activated by gp63. The cells from Danish donors produced either IFN-gamma or IL-4, but not both cytokines after incubation with the crude preparation of L. major antigens. The data show that the T cell response to Leishmania antigens in humans who have had uncomplicated CL or subclinical L. major infection is an IFN-gamma-producing Th1-like response.
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