ArticleActa neurochirurgica1994
Platelet-activating factor (PAF) and the development of chronic subdural haematoma.
Article in Acta neurochirurgica, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Tranexamic Acid in Chronic Subdural Hematomas (TRACS): study protocol for a randomized controlled trial.Trials · 2016Trial
- Molecular and Pathophysiological Mechanisms Underlying Chronic Subdural Hematoma Recurrence: A Comprehensive Review.Neuromolecular medicine · 2026Review
- Local and systemic pro-inflammatory and anti-inflammatory cytokine patterns in patients with chronic subdural hematoma: a prospective study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma.Neurosurgical review · 2006Article
- Platelet-activating factor (PAF) and the formation of chronic subdural haematoma. Measurement of plasma PAF levels and anti-PAF immunoglobulin titers.Acta neurochirurgica · 1995Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet activating factor (PAF) content and PAF-acetylhydrolase (PAFAH) activity were measured in the plasma and haematoma of 34 chronic subdural haematoma (CSH) patients. The plasma PAF level in patients with CSH was higher than that in healthy controls. Although there was no correlation between the plasma PAF levels and the interval between the onset of symptoms and the day of sampling, namely, the interval after bleeding, the haematoma PAF level gradually decreased according to the interval after the onset of symptoms. There was no difference between plasma PAFAH activity in patients with CSH and that in healthy controls, and haematoma enzyme activity gradually increased correlated with the interval between the onset of symptoms and surgery. In addition, the localization of PAF in haematoma capsules was histochemically determined. PAF was solely localized to the peri-sinusoidal vessels in the outer membrane of haematoma capsules. Based on these biochemical and histochemical studies, we speculated that PAF may play a role in the development of chronic subdural haematomas.
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