Evidence map›Paper›PMID 7993390›Full record

ArticleImmunogenetics1994

P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.

D L Gasser, N L Sternberg, J C Pierce, A Goldner-Sauve, H Feng, A K Haq, T Spies, C Hunt, K H Buetow, D D Chaplin

Abstract read
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In one paragraph

Article in Immunogenetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013
    Review
  3. A physical map of the mouse H2 Bat5/Db interval.Mammalian genome : official journal of the International Mammalian Genome Society · 1997
    Article
  4. Article
  5. Review
  6. The P1 cloning system: past and future.Mammalian genome : official journal of the International Mammalian Genome Society · 1994
    Review
  7. Preparation and screening of an arrayed human genomic library generated with the P1 cloning system.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

D L GasserDepartment of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
N L Sternberg
J C Pierce
A Goldner-Sauve
H Feng
A K Haq
T Spies
C Hunt
K H Buetow
D D Chaplin
University of Pennsylvania · USDuPont (United States) · USFox Chase Cancer Center · USHarvard University · USMallinckrodt (United States) · USWashington University in St. Louis · US

Funding

SULFHYDRYL REACTIVITY FOR LYMPHOCYTE MITOGENESISP50AI015322 · NIAID · WASHINGTON UNIVERSITY · PI UNANUE, EMIL R · 1985 to 1992
–
CRANIOFACIAL ANOMALIESP50DE009164 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI GASSER, DAVID L · 1989 to 1993
–
HSP70 REGULATION IN CELLS RECOVERING FROM HYPERTHORMIAR29CA050503 · NCI · WASHINGTON UNIVERSITY · PI HUNT, CLAYTON R · 1990 to 1994
–
NCI NIH HHS R29 CA50 503NIAID NIH HHS AI 15322NIDCR NIH HHS P50-DE09164
6 · The paper itself

Abstract

A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes that are homologous to genes initially mapped within the human major histocompatibility complex. These include the mouse homologs of BAT2 (HLA-B-associated transcript 2) through BAT9 and also three HSP70-related genes. Five P1 clones form a contig of 240 kb that spans from BAT9 through BAT3. Twelve cosmid clones are arranged in three contigs that confirm most of the structure of the P1 contig and link the mouse BAT3 homolog to the BAT2 homolog approximately 15 kb farther telomeric. Polymorphic DNA markers within the cloned region were used to map the cleft palate susceptibility-1 (Cps-1) locus to the interval between Hsp70.1 and BAT6 (valyl-tRNA synthetase). This refines the location of the Cps-1 locus to a 45 kb region contained in the H2-124 P1 insert.

Indexed as

Adenosine TriphosphatasesAnalysis of VarianceAnimalsBacteriophage P1Base SequenceBlotting, SouthernCleft PalateCloning, MolecularCosmidsDNA PrimersDNA ProbesElectrophoresis, Agar GelFemaleGene LibraryGenetic LinkageGenotypeAdenosine TriphosphatasesDNA PrimersDNA ProbesH-2 AntigensHeat-Shock Proteins

Identifiers

PMID7993390
OpenAlexW2092541291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.