ArticleProceedings of the National Academy of Sciences of the United States of America1994
Pancreatic beta cells express a diverse set of homeobox genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 156 citations in OpenAlex.
- Post translational modification regulation of transcription factors governing pancreatic β-cell identity and functional mass.Frontiers in endocrinology · 2025Review
- High-Throughput Methods for the Discovery of Small Molecule Modulators of Pancreatic Beta-Cell Function and Regeneration.Assay and drug development technologies · 2024Review
- NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer.International journal of molecular sciences · 2020Article
- Changes of MODY signal pathway genes in the endoplasmic reticulum stress in INS-1-3 cells.PloS one · 2018Article
- Comparison of enteroendocrine cells and pancreatic β-cells using gene expression profiling and insulin gene methylation.PloS one · 2018Article
- Article
- NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition.Oncogene · 2016Article
- Article
- The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide.Molecular and cellular biochemistry · 2014Article
- Generation of β cells from human pluripotent stem cells: are we there yet?Annals of the New York Academy of Sciences · 2014Review
- Derivation of insulin-producing beta-cells from human pluripotent stem cells.The review of diabetic studies : RDS · 2014Review
- Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.PLoS genetics · 2013Article
- BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation.PloS one · 2013Article
- Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults.EMBO molecular medicine · 2013Article
- Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas.Diabetologia · 2012Article
- The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.Development (Cambridge, England) · 2011Article
- The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.Diabetes · 2010Article
- On the origin of the beta cell.Genes & development · 2008Review
- Expression and function of Nkx6.3 in vertebrate hindbrain.Brain research · 2008Article
- Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum.Molecular and cellular biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Homeobox genes, which are found in all eukaryotic organisms, encode transcriptional regulators involved in cell-type differentiation and development. Several homeobox genes encoding homeodomain proteins that bind and activate the insulin gene promoter have been described. In an attempt to identify additional beta-cell homeodomain proteins, we designed primers based on the sequences of beta-cell homeobox genes cdx3 and lmx1 and the Drosophila homeodomain protein Antennapedia and used these primers to amplify inserts by PCR from an insulinoma cDNA library. The resulting amplification products include sequences encoding 10 distinct homeodomain proteins; 3 of these proteins have not been described previously. In addition, an insert was obtained encoding a splice variant of engrailed-2, a homeodomain protein previously identified in the central nervous system. Northern analysis revealed a distinct pattern of expression for each homeobox gene. Interestingly, the PCR-derived clones do not represent a complete sampling of the beta-cell library because no inserts encoding cdx3 or lmx1 protein were obtained. Beta cells probably express additional homeobox genes. The abundance and diversity of homeodomain proteins found in beta cells illustrate the remarkable complexity and redundancy of the machinery controlling beta-cell development and differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.