ArticleProceedings of the National Academy of Sciences of the United States of America1994
(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 118 citations in OpenAlex.
- Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.The Prostate · 2011Article
- Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer.Cancer science · 2010Article
- Stromal cell expression of caveolin-1 predicts outcome in breast cancer.The American journal of pathology · 2009Article
- Caveolin-1 expression in benign and malignant lesions of the breast.World journal of surgical oncology · 2007Article
- Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis.Cancer cell international · 2007Article
- ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix.Oncogene · 2006Article
- Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status.The American journal of pathology · 2006Article
- Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity.World journal of gastroenterology · 2006Article
- Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness.The American journal of pathology · 2006Article
- Caveolin-1 inhibits breast cancer growth and metastasis.Oncogene · 2004Article
- Expression of the prolactin-inducible protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate.Cancer science · 2004Article
- Molecular cytogenetic investigations of synchronous bilateral breast cancer.Journal of clinical pathology · 2003Article
- Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation.The American journal of pathology · 2003Article
- Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.Molecular biology of the cell · 2003Article
- Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia.The American journal of pathology · 2002Article
- Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability.Oncogene · 2002Article
- HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue.Molecular and cellular biology · 2001Article
- Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.The EMBO journal · 2001Article
- The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein.Oncogene · 2001Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Loss of heterozygosity in human chromosome 7q was studied to determine the location of a putative tumor suppressor gene. Twenty-six of 31 cases studied presented loss of heterozygosity at one or more loci on chromosome 7q. Eighty-three percent loss of heterozygosity (in 11 informative cases) was detected by using the (C-A)n microsatellite repeat marker D7S522 at 7q31.1-7q31.2. These results suggest that a tumor suppressor gene relevant to the development of breast cancer is present in the 7q31.1-7q31.2 region, confirming our previous evidence for a tumor suppressor gene in this chromosome and frequent deletions of the long arm in human primary breast cancers.
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