ArticleProceedings of the National Academy of Sciences of the United States of America1994
Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- TERRA and Telomere Maintenance in the YeastGenes · 2023Review
- Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts inRNA biology · 2023Article
- Global genomic instability caused by reduced expression of DNA polymerase ε in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Snail1 transcription factor controls telomere transcription and integrity.Nucleic acids research · 2018Article
- TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast.PloS one · 2018Article
- Article
- The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance.Epigenetics · 2017Article
- Spatiotemporal analysis with a genetically encoded fluorescent RNA probe reveals TERRA function around telomeres.Scientific reports · 2016Article
- Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.PLoS genetics · 2016Article
- TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe.EMBO reports · 2016Article
- SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy.Genome research · 2015Article
- Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.Epigenetics · 2014Article
- Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation.RNA biology · 2014Article
- Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence.Nature structural & molecular biology · 2013Article
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence.Nucleic acids research · 2012Article
- Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast.Nucleic acids research · 2012Article
- The telomeric transcriptome of Schizosaccharomyces pombe.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Telomeres are required for the stable maintenance of chromosomes in the yeast Saccharomyces cerevisiae. Telomeres also repress the expression of genes in their vicinity, a phenomenon known as telomere position effect. In an attempt to construct a conditional telomere, an inducible promoter was introduced adjacent to a single telomere of a chromosome such that transcription could be induced toward the end of the chromosome. Transcription toward two other essential chromosomal elements, centromeres and origins of replication, eliminates their function. In contrast, transcription toward a telomere did not affect the stability function of the telomere as measured by the loss rate of the transcribed chromosome. Transcription proceeded through the entire length of the telomeric tract and caused a modest reduction in the average length of the transcribed telomere. Transcription of the telomere substantially reduced the frequency of cells in which an adjacent URA3 gene was subject to telomere position effect. These results indicate that telomere position effect can be alleviated without compromising chromosome stability.
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Registered trials
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