ArticleNaunyn-Schmiedeberg's archives of pharmacology1994
Comparison of cloned and pharmacologically defined rat tissue alpha 1-adrenoceptor subtypes.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Radioreceptor assay analysis of tamsulosin and terazosin pharmacokinetics.British journal of clinical pharmacology · 1998Trial
- α₁A-adrenergic receptors regulate cardiac hypertrophy in vivo through interleukin-6 secretion.Molecular pharmacology · 2013Article
- Characterization of the alpha1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter.British journal of pharmacology · 2008Article
- Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate.British journal of pharmacology · 2006Review
- Review
- Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms.Drugs & aging · 2002Review
- Alpha-1 adrenergic signaling in a cardiac murine atrial myocyte (HL-1) cell line.Molecular and cellular biochemistry · 2000Article
- The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor.British journal of pharmacology · 1996Article
- Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies.British journal of pharmacology · 1996Article
- Analysis of the activity of alpha 1-adrenoceptor antagonists in rat aorta.British journal of pharmacology · 1996Article
- Detection of alpha 1-adrenoceptor subtypes in human hypertrophied prostate by in situ hybridization.The Histochemical journal · 1996Article
- Comparison of guinea-pig, bovine and rat alpha 1-adrenoceptor subtypes.British journal of pharmacology · 1996Article
- Effects of noradrenaline and neuropeptide Y on rat mesenteric microvessel contraction.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline.British journal of pharmacology · 1995Article
- Classification of alpha 1-adrenoceptor subtypes.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Functional evidence equating the pharmacologically-defined alpha 1A- and cloned alpha 1C-adrenoceptor: studies in the isolated perfused kidney of rat.British journal of pharmacology · 1995Article
- Comparison of alpha 1A- and alpha 1B-adrenoceptor coupling to inositol phosphate formation in rat kidney.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Multiple alpha 1-adrenoceptor subtypes have been defined by pharmacological and receptor cloning techniques, but the precise alignment of cloned and pharmacologically-defined subtypes is still unclear. We have compared the affinities of 8 subtype-selective compounds at three cloned alpha 1-adrenoceptor subtypes (rat alpha 1B, bovine alpha 1C, rat alpha 1A/D) with those previously determined by the same methods in rat spleen, cerebral cortex, and kidney (Naunyn-Schmiedeberg's Arch. Pharmacol. 348: 385-395, 1993). Among all compounds tested to date at cloned alpha 1-adrenoceptor subtypes (+)-tamsulosin appears to be the most selective with a rank order of potency alpha 1C > alpha 1A/D > or = alpha 1B. Affinities for the alpha 1A-selective 5-methyl-urapidil, methoxamine, oxymetazoline, phentolamine and (-)- and (+)-tamsulosin and for noradrenaline and SDZ NVI-085 at the splenic alpha 1B-adrenoceptors and at their low affinity sites in cerebral cortex and kidney correlated best with those at the cloned alpha 1B-adrenoceptor. Affinities of these drugs at their high affinity sites in cerebral cortex (pharmacologically-defined alpha 1A-adrenoceptor) were matched best by those at the cloned alpha 1C-adrenoceptor. Rat kidney appears to contain two chloroethylclonidine-resistant alpha 1-adrenoceptor subtypes one of which is similar to the cloned alpha 1C- and one to the cloned alpha 1A/D-adrenoceptor. We conclude that the cloned alpha 1B-adrenoceptor is the genetic correlate of the pharmacologically-defined alpha 1B-adrenoceptor. An alpha 1-adrenoceptor subtype corresponding to the cloned alpha 1A/D-adrenoceptor appears to exist in rat kidney.(ABSTRACT TRUNCATED AT 250 WORDS)
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