ArticleThe Journal of clinical investigation1994
Growth inhibition of the intestinal parasite Giardia lamblia by a dietary lectin is associated with arrest of the cell cycle.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Parasitological, Molecular, and Histopathological Investigation of the Potential Activity of Propolis and Wheat Germ Oil against Acute Toxoplasmosis in Mice.Pharmaceutics · 2023Article
- In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Deep glance on the antiparasitic anticancer activities of wheat germ oil in chronically infected immunosuppressed mice with cryptosporidiosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Gut-brain axis: Review on the association between Parkinson's disease and plant lectins.Archive of clinical cases · 2022Review
- Microtubule organelles in Giardia.Advances in parasitology · 2020Review
- Ethanol and isopropanol in concentrations present in hand sanitizers sharply reduce excystation of Giardia and Entamoeba and eliminate oral infectivity of Giardia cysts in gerbils.Antimicrobial agents and chemotherapy · 2015Article
- Review
- Giardia flagellar motility is not directly required to maintain attachment to surfaces.PLoS pathogens · 2011Article
- The old and new therapeutic approaches to the treatment of giardiasis: where are we?Biologics : targets & therapy · 2009Article
- Cell cycle synchrony in Giardia intestinalis cultures achieved by using nocodazole and aphidicolin.Eukaryotic cell · 2008Article
- Inhibition of Giardia intestinalis by extracellular factors from Lactobacilli: an in vitro study.Applied and environmental microbiology · 2001Article
- Ginger and cinnamon: can this household remedy treat giardiasis? Parasitological and histopathological studies.Iranian journal of parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Giardia lamblia, a cause of diarrheal disease throughout the world, is a protozoan parasite that thrives in the small intestine. It is shown here that wheat germ agglutinin (WGA), a naturally occurring lectin widely consumed in normal human diets, reversibly inhibits the growth of G. lamblia trophozoites in vitro, and reduces infection by G. muris in the adult mouse model of giardiasis. The inhibitory effect was dose related, not associated with cytotoxicity and reversed by N-acetyl-D-glucosamine in accordance with the known specificity of the lectin and in agreement with the presence of GlcNAc residues on the surface membrane of G. lamblia trophozoites. Cell cycle analysis revealed that parasites grown in the presence of WGA are arrested in the G2/M phase, providing an explanation for the lectin-induced inhibition of cell proliferation. Comparison of electrophoretic profiles by lectin blot analysis revealed both glycoprotein induction and suppression in growth-arrested organisms. Our findings raise the possibility that blocking trophozoite growth with naturally occurring dietary lectins may influence the course of giardiasis. In addition, the study of cell cycle arrest by WGA may provide a model to study the regulation of cell division in lower eukaryotes.
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Registered trials
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