ReviewExperientia1994
Heat shock proteins in immune response to cancer: the Fourth Paradigm.
Review in Experientia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 77 citations in OpenAlex.
- A new weapon: the application of tumor vaccines based on extracellular exosomal heat shock proteins in immunotherapy.Frontiers in immunology · 2025Review
- Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Frontiers in immunology · 2022Article
- Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.Frontiers in immunology · 2016Review
- Molecular chaperones, α-synuclein, and neurodegeneration.Molecular neurobiology · 2013Review
- Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation.Cell stress & chaperones · 2011Article
- More than just tumor destruction: immunomodulation by thermal ablation of cancer.Clinical & developmental immunology · 2011Review
- Chaperokine function of recombinant Hsp72 produced in insect cells using a baculovirus expression system is retained.The Journal of biological chemistry · 2010Article
- Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.Cell stress & chaperones · 2004Review
- Heat shock proteins in the genitourinary system.Current urology reports · 2003Review
- Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.Cell stress & chaperones · 2000Article
- Natural autoantibodies against heat-shock proteins hsp70 and gp96: implications for immunotherapy using heat-shock proteins.Immunology · 2000Article
- The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Heat shock protein-based therapeutic strategies against human immunodeficiency virus type 1 infection.Infectious diseases in obstetrics and gynecology · 1999Review
- Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity.The Journal of experimental medicine · 1997Article
- Molecular mechanisms involved in the association of HLA-DR4 and rheumatoid arthritis.Immunologic research · 1997Review
- Antigen processing in vivo and the elicitation of primary CTL responses.Journal of immunology (Baltimore, Md. : 1950) · 1995Article
- Hsp70--a multi-gene, multi-structure, multi-function family with potential clinical applications.Experientia · 1994Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of heat shock proteins in immune response is categorized into four distinct paradigms. In the First Paradigm, HSP derived from foreign organisms act as classical foreign antigens, and they elicit immune response to the non-conserved HSP epitopes. The Second Paradigm refers to instances where the host responds to self HSP to which there is no central or peripheral tolerance. The Third Paradigm involves molecular mimicry, where cross-reactivity between an HSP and another protein leads to an immune response to the latter under conditions which elicit an immune response to the former, such as infection with a bacterium whose immunodominant antigen is an HSP. The Fourth Paradigm refers to situations where an HSP-antigen complex elicits an effective response to the antigen and not to the HSP. Thus the HSP acts as a carrier for the antigenic peptide. The role of HSP in recognition by gamma delta T cells may also fall into this paradigm. In this article, the Fourth Paradigm is considered as a crucial element in the development of vaccines against cancers and infectious diseases, and is analyzed through the prism of the observed association of hsp70 species with antigenic peptides.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.