ArticleThe EMBO journal1994
The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2020Review
- Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation.PLoS biology · 2014Article
- HIV: cell binding and entry.Cold Spring Harbor perspectives in medicine · 2012Review
- HIV-1 glycoprotein 41 ectodomain induces activation of the CD74 protein-mediated extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to enhance viral infection.The Journal of biological chemistry · 2011Article
- Macrophage signaling in HIV-1 infection.Retrovirology · 2010Review
- Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.The Journal of clinical investigation · 2006Article
- Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry.Retrovirology · 2006Article
- HIV-1 infection is facilitated in T cells by decreasing p56lck protein tyrosine kinase activity.Clinical and experimental immunology · 2003Article
- The level of CD4 expression limits infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses.Journal of virology · 2000Article
- HIV-1 Nef increases T cell activation in a stimulus-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4.Journal of virology · 1998Article
- Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4.Journal of virology · 1998Article
- The kappaB sites in the human immunodeficiency virus type 1 long terminal repeat enhance virus replication yet are not absolutely required for viral growth.Journal of virology · 1997Article
- Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax.Journal of virology · 1997Article
- Inhibition of human immunodeficiency virus type 1 production in infected peripheral blood mononuclear cells by human leukocyte antigen class I-specific antibodies: evidence for a novel antiviral mechanism.Journal of virology · 1996Article
- Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.Microbiological reviews · 1996Review
- Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule.Journal of virology · 1996Article
- HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.The Journal of experimental medicine · 1996Article
- The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4.Journal of virology · 1995Article
- Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4.Journal of virology · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role played by the cytoplasmic domain of the CD4 molecule in the process of HIV infection was investigated, using A2.01 cells which express different forms of the CD4 gene. A delay in HIV production was consistently observed in cells expressing a truncated CD4 which lacks the cytoplasmic domain (CD4.401) compared with cells expressing the wild type CD4. The delay was much less in cells expressing a hybrid CD4-CD8 molecule (amino acids 1-177 of CD4 fused to the hinge, transmembrane and cytoplasmic domains of CD8). Yet the extent of viral entry and reverse transcription, monitored by semi-quantitative PCR, was similar in each cell type studied. For further study of the mechanism responsible for delayed HIV replication in the A2.01/CD4.401 cell line, cells were treated with phytohaemagglutinin (PHA), 24 h after HIV infection. Under such experimental conditions HIV production was detected at the same time in the culture supernatants of A2.01/CD4 and A2.01/CD4.401 cells. Moreover, we found that CD4 oligomerization by HIV-1 induced NF-kappa B translocation in A2.01/CD4 and A2.01/CD4-CD8 but not in A2.01/CD4.401 cells. This was consistent with CAT assay experiments which provided evidence for Tat-independent NF-kappa B mediated activation of HIV-1 LTR promoter after HIV binding to CD4 in A2.01/CD4 and A2.01/CD4-CD8 but not in A2.01/CD4.401 cells. In contrast to results published recently by Tremblay et al. (1994, EMBO J., 13, 774-783), we propose that a positive cellular signal initiated following oligomerization of the CD4 by the virus itself is involved in NF-kappa B-dependent early HIV transcription in A2.01/CD4 cells.
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