Evidence map›Paper›PMID 7988284›Full record

ReviewChromosoma1994

Probing chromatin with the scanning force microscope.

W Fritzsche, A Schaper, T M Jovin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chromosoma, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. DNA release dynamics from reducible polyplexes by atomic force microscopy.Langmuir : the ACS journal of surfaces and colloids · 2008
    Article
  2. Atomic force microscopy for imaging human metaphase chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008
    Review
  3. CHRONIS: an animal chromosome image database.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005
    Article
  4. Article
  5. Stretching and imaging single DNA molecules and chromatin.Journal of muscle research and cell motility · 2002
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Imaging ROMK1 inwardly rectifying ATP-sensitive K+ channel protein using atomic force microscopy.Proceedings of the National Academy of Sciences of the United States of America · 1996
    Article
  12. Atomic force microscopy of plant chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1995
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

W FritzscheDepartment of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
A Schaper
T M Jovin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the scanning force microscope (SFM), one can image the topography of biological material adsorbed at air-solid or liquid-solid interfaces with up to nanometer resolution. In principle, fixation, contrast enhancement, and labeling are not required. We have adapted specimen preparation techniques of conventional electron microscopy for visualizing chromatin ultrastructures in the SFM. A beaded substructure of the nucleoprotein filament was obtained after hypotonic lysis of chicken erythrocytes and air drying. The beads-on-a-string morphology of the basic nucleosomal assembly was well delineated. The nucleosomes appeared as round protrusions with an apparent height of 4-6 nm. The histogram of center-to-center distances between adjacent nucleosome cores along the filament axis had a peak at approximately 30 nm. Reversible changes in the three-dimensional structure were observed upon exposure of air-dried samples of metaphase chromosomes to solutions of different ionic strengths.

Indexed as

AnimalsCell MovementChromatinChromosomesFeasibility StudiesHumansMetaphaseMicroscopyWaterChromatinWater

Identifiers

PMID7988284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.