ArticleAntimicrobial agents and chemotherapy1994
Efficacy of azithromycin as a causal prophylactic agent against murine malaria.
Article in Antimicrobial agents and chemotherapy, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Cethromycin pharmacokinetics and pharmacodynamics for single dose cure ofAntimicrobial agents and chemotherapy · 2025Article
- The human malaria-Antimicrobial agents and chemotherapy · 2024Review
- Novel Therapeutics for Malaria.Pharmaceutics · 2023Review
- Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens.NPJ vaccines · 2022Article
- Multipurpose Drugs Active Against BothFrontiers in cellular and infection microbiology · 2021Review
- Repurposing Drugs to Fight Hepatic Malaria Parasites.Molecules (Basel, Switzerland) · 2020Review
- Suppressive effect of azithromycin on Plasmodium berghei mosquito stage development and apicoplast replication.Malaria journal · 2010Article
- A pre-emptive strike against malaria's stealthy hepatic forms.Nature reviews. Drug discovery · 2009Review
- Pharmacodynamics of doxycycline in a murine malaria model.Antimicrobial agents and chemotherapy · 2007Article
- Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?Malaria journal · 2007Review
- Recent Advances in the Prophylaxis and Treatment of Malaria.Current infectious disease reports · 2001Article
- Evaluation of selected antiprotozoal drugs in the Babesia microti-hamster model.Antimicrobial agents and chemotherapy · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of the newly marketed azalide azithromycin was compared with that of the clinical agent doxycycline in a murine model of sporozoite-induced malaria. Drug was administered once; Plasmodium yoelii sporozoites were administered 2 h later; survival at day 60 was determined. For parenterally administered drug, 160 mg of azithromycin or doxycycline per kg of body weight was 100% effective; 40 mg of azithromycin per kg was 80% effective, but 40 mg of doxycycline per kg was 40% effective. Orally administered azithromycin was somewhat less effective than parenterally administered drug, consistent with the 37% clinical oral bioavailability of this agent. For orally administered azithromycin, 160 mg/kg was 100% effective and 40 mg/kg was 40% effective. The efficacy of azithromycin in comparison with that of doxycycline and the known prolonged levels of azithromycin in the livers of humans suggest that azithromycin has potential as a clinical causal prophylactic agent for malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.