ArticleNucleic acids research1994
GAGA factor and TBF1 bind DNA elements that direct ubiquitous transcription of the Drosophila alpha 1-tubulin gene.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation.Cellular and molecular life sciences : CMLS · 2018Review
- p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila.Molecular biology reports · 2013Article
- Paused Pol II captures enhancer activity and acts as a potent insulator.Genes & development · 2009Article
- Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Tissue-dependent enhancement of transgene expression by introns of replacement histone H3 genes of Arabidopsis.Plant molecular biology · 2001Article
- Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation.Nucleic acids research · 1997Review
- Common features of analogous replacement histone H3 genes in animals and plants.Journal of molecular evolution · 1996Article
- Purification and physical properties of the male and female double sex proteins of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Analysis of the mitochondrial ATP synthase beta-subunit gene in Drosophilidae: structure, transcriptional regulatory features and developmental pattern of expression in Drosophila melanogaster.The Biochemical journal · 1995Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Three DNA regions (TE1, TE2 and the intron) regulate the ubiquitous expression of the alpha 1-tubulin gene of Drosophila melanogaster. In this report, we identify two proteins that bind these DNA regions. One is the previously characterized GAGA transcription factor and the other is a newly identified 62 kDa polypeptide, TBF1 (TE1-binding factor 1). Purified GAGA factor binds three sites in TE2 and at least three in the intron. TBF1 was purified from embryos and binds to both TE1 and TE2. Together, the two proteins produce the same DNase I footprints in TE1 and TE2 as does a nuclear extract that transcribes the gene accurately. These footprints cover most of the TE1 and TE2 DNA. Moreover, one binding site for each protein coincides with a site that activates transcription in vitro. The characteristics of the GAGA factor and the genes it regulates suggest roles these two proteins are likely to play in regulating ubiquitous expression.
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