Evidence map›Paper›PMID 7982562›Full record

ArticleGenetics1994

Genetic instability at the agouti locus of the mouse (Mus musculus). I. Increased reverse mutation frequency to the Aw allele in A/a heterozygotes.

R Sandulache, A Neuhäuser-Klaus, J Favor

Abstract readComparative Study
In one paragraph

Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

R SandulacheInstitut für Säugetiergenetik, GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Federal Republic of Germany.
A Neuhäuser-Klaus
J Favor

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have compiled the reverse mutation rate data to the white bellied agouti (Aw) allele in heterozygous A/a mice and shown it to be increased by a factor of at least 350 in comparison to the reverse mutation rate in homozygous a/a mice. Employing tightly linked flanking restriction fragment length polymorphism DNA markers, we have shown that reversion to Aw is associated with crossing over in the vicinity of the agouti locus. The non-agouti (a) allele has been recently shown to contain an 11-kb insert within the first intron of the agouti gene. Together with our present results, these observations suggest possible mechanisms to explain the reversion events.

Indexed as

AllelesIntercellular Signaling Peptides and ProteinsAgouti Signaling ProteinAnimalsCrossing Over, GeneticDNA Mutational AnalysisEthylnitrosoureaFemaleHeterozygoteMaleMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred DBAMice, Mutant StrainsModels, GeneticAgouti Signaling ProteinEthylnitrosoureaIntercellular Signaling Peptides and ProteinsProteins

Identifiers

PMID7982562
PMCPMC1206055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.