ArticleGenetics1994
The effects of mutation and natural selection on codon bias in the genes of Drosophila.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Selection on synonymous codon usage in soybean (Glycine max) WRKY genes.Scientific reports · 2024Article
- The Patterns of Codon Usage between Chordates and Arthropods are Different but Co-evolving with Mutational Biases.Molecular biology and evolution · 2024Article
- Genome-wide analysis of codon usage in sesame (Heliyon · 2022Article
- Review
- Article
- Article
- Patterns of Ancestral Animal Codon Usage Bias Revealed through Holozoan Protists.Molecular biology and evolution · 2018Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Analytical Biases Associated with GC-Content in Molecular Evolution.Frontiers in genetics · 2017Article
- The Selective Advantage of Synonymous Codon Usage Bias in Salmonella.PLoS genetics · 2016Article
- Article
- Studying patterns of recent evolution at synonymous sites and intronic sites in Drosophila melanogaster.Journal of molecular evolution · 2010Article
- Measuring and detecting molecular adaptation in codon usage against nonsense errors during protein translation.Genetics · 2009Article
- Effect of exonic splicing regulation on synonymous codon usage in alternatively spliced exons of Dscam.BMC evolutionary biology · 2009Article
- Developmental stage and level of codon usage bias in Drosophila.Molecular biology and evolution · 2008Article
- Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster.Genome research · 2008Article
- Codon bias is a major factor explaining phage evolution in translationally biased hosts.Journal of molecular evolution · 2008Article
- Article
- Article
- Gender-specific selection on codon usage in plant genomes.BMC genomics · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Codon bias varies widely among the loci of Drosophila melanogaster, and some of this diversity has been explained by variation in the strength of natural selection. A study of correlations between intron and coding region base composition shows that variation in mutation pattern also contributes to codon bias variation. This finding is corroborated by an analysis of variance (ANOVA), which shows a tendency for introns from the same gene to be similar in base composition. The strength of base composition correlations between introns and codon third positions is greater for genes with low codon bias than for genes with high codon bias. This pattern can be explained by an overwhelming effect of natural selection, relative to mutation, in highly biased loci. In particular, this correlation is absent when examining fourfold degenerate sites of highly biased genes. In general, it appears that selection acts more strongly in choosing among fourfold degenerate codons than among twofold degenerate codons. Although the results indicate regional variation in mutational bias, no evidence is found for large scale regions of compositional homogeneity.
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