ArticleBiochemical genetics1994
Drosophila melanogaster genes encoding three troponin-C isoforms and a calmodulin-related protein.
Article in Biochemical genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Molecular cloning and characterization of calmodulin-like protein CaLP from the Scleractinian coral Galaxea astreata.Cell stress & chaperones · 2018Article
- Mechanotransduction via the LINC complex regulates DNA replication in myonuclei.The Journal of cell biology · 2018Article
- Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T inG3 (Bethesda, Md.) · 2017Article
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- Article
- Regulating the contraction of insect flight muscle.Journal of muscle research and cell motility · 2011Review
- Electron microscopy and three-dimensional reconstruction of native thin filaments reveal species-specific differences in regulatory strand densities.Biochemical and biophysical research communications · 2010Article
- Diversification and independent evolution of troponin C genes in insects.Journal of molecular evolution · 2005Article
- A genomewide survey of developmentally relevant genes in Ciona intestinalis. IX. Genes for muscle structural proteins.Development genes and evolution · 2003Article
- Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect.The Biochemical journal · 2003Article
- Conformational and metal-binding properties of androcam, a testis-specific, calmodulin-related protein from Drosophila.Protein science : a publication of the Protein Society · 1999Article
- Genomic organization, expression, and analysis of the troponin C gene pat-10 of Caenorhabditis elegans.The Journal of cell biology · 1999Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using low-stringency hybridization and polymerase chain reaction (PCR)-based DNA amplification, we have isolated three Drosophila melanogaster genes that encode troponin-C isoforms and one specifying a protein that is closely related to calmodulin. Two of the troponin-C genes, located within the 47D and 73F subdivisions of chromosomes 2 and 3, respectively, encode very closely related isoforms. That specified by the 47D gene accumulates almost exclusively in larval muscles, while that encoded by the 73F gene is present in both larvae and adults. The third gene, located within the 41C subdivision of chromosome 2, encodes a more distantly related troponin-C isoform that accumulates only within adults. The gene that encodes the calmodulin-related protein is located within the 97A subdivision of chromosome three. The protein encoded by this gene has a different primary sequence from that of conventional calmodulin, which is specified by a gene located within the 49A subdivision of chromosome 2. Our report is the first to describe insect troponin-C isoforms and further avails genetic methods for investigating the in vivo functions of the troponin-C/myosin light-chain/calmodulin protein superfamily.
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